Human Anti-GP6 Recombinant Antibody (clone glenzocimab)
CAT#: VS-0624-FY8
This is a human recombinant antibody with high affinity for GPVI. It prevents binding of both ligands through a combination of steric hindrance and structural changes. Glenzocimab does not bind to a truncated GPVI missing loop residues 129 to 136, validating the epitope identified in the crystal structure. Glenzocimab inhibits GPVI dimerization and aggregation. The EC₅₀ value of GPVI-Fc was of 85 ng/mL.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47611/1925_A11_24_cr5cd55a323d93f_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66482/149862_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HEL, K-562, U-2 OS)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000088053-GP6
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Specifications
- Host Species
- Human
- Type
- Human IgG1 kappa
- Specificity
- Human GP6
- Species Reactivity
- Human
- Clone
- glenzocimab
- Applications
- Inhibition
- Related Disease
- Autoimmune disease
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GP6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-003CT | Anti-Human GPVI Recombinant Antibody (1C3) | Funcs, ELISA, Inhib, FC | Human antibody |
| TAB-003CT-S(P) | Anti-Human GPVI Recombinant Antibody scFv Fragment (1C3) | Funcs, ELISA, Inhib, FC | Human antibody |
| TAB-003CT-F(E) | Anti-Human GPVI Recombinant Antibody Fab Fragment (1C3) | ELISA, Inhibition, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-005CT | Mouse Anti-GP6 Recombinant Antibody (TAB-005CT) | WB, ELISA, Block | Mouse IgG1, κ |
| TAB-005CT-S(P) | Mouse Anti-GP6 Recombinant Antibody; scFv Fragment (TAB-005CT-S(P)) | WB, ELISA, Block | Mouse scFv |
| TAB-005CT-F(E) | Mouse Anti-GP6 Recombinant Antibody; Fab Fragment (TAB-005CT-F(E)) | WB, ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1483 | Hi-Affi™ Rabbit Anti-GP6 Recombinant Antibody (clone DS1483AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-CN-S(P) | Human Anti-GP6 Recombinant Antibody; scFv Fragment (HPAB-0002-CN-S(P)) | FC, WB | Humanized scFv |
| HPAB-0003-CN-S(P) | Human Anti-GP6 Recombinant Antibody; scFv Fragment (HPAB-0003-CN-S(P)) | FC, WB | Humanized scFv |
| HPAB-0004-CN-S(P) | Mouse Anti-GP6 Recombinant Antibody; scFv Fragment (HPAB-0004-CN-S(P)) | FC, WB | Mouse scFv |
| HPAB-0133CQ-S(P) | Human Anti-GP6 Recombinant Antibody (clone hGP 5C4); scFv Fragment | ELISA, FC, Inhib, FuncS | Humanized scFv |
| FAMAB-0101JF-S(P) | Mouse Anti-GP6 Recombinant Antibody (clone 12A5); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-CN-F(E) | Human Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0002-CN-F(E)) | FC, WB | Humanized Fab |
| HPAB-0003-CN-F(E) | Human Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0003-CN-F(E)) | FC, WB | Humanized Fab |
| HPAB-0004-CN-F(E) | Mouse Anti-GP6 Recombinant Antibody; Fab Fragment (HPAB-0004-CN-F(E)) | FC, WB | Mouse Fab |
| HPAB-0133CQ-F(E) | Human Anti-GP6 Recombinant Antibody (clone hGP 5C4); Fab Fragment | ELISA, FC, Inhib, FuncS | Humanized Fab |
| FAMAB-0101JF-F(E) | Mouse Anti-GP6 Recombinant Antibody (clone 12A5); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1711-FY | Human Anti-GP6 Recombinant Antibody (clone F1245-4-1) | ELISA, WB, IHC | Chimeric (mouse/human) IgG |
| HPAB-1712-FY | Human Anti-GP6 Recombinant Antibody (clone F1245-5-1) | ELISA, WB, IHC | Chimeric (mouse/human) IgG |
| HPAB-1713-FY | Human Anti-GP6 Recombinant Antibody (clone F1245-6-2) | ELISA, WB, IHC | Chimeric (mouse/human) IgG |
| HPAB-1714-FY | Human Anti-GP6 Recombinant Antibody (clone F1232-7-1) | ELISA | Human IgG |
| HPAB-1715-FY | Human Anti-GP6 Recombinant Antibody (clone F1232-18-3) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC373 | Recombinant Anti-GP6 Vesicular Antibody, EV Displayed (VS-0425-YC373) | ELISA, FC, Inhib, Cell-uptake |
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