Mouse Anti-ITGAM Recombinant Antibody (clone 3A4B10) (CAT#: VS7-0425-WR157)
This product is a mouse IgG1 recombinant antibody that binds to human ITGAM. The antibody 3A4B10 recognizes a specific amino acid domain of human ITGAM (AA: 623-728). It can be used for IHC and FC assays.
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Normal Tissue
RNA Expression
Figure 1 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2274/158194_A_8_8.jpg
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2274/158194_A_8_8.jpg
Figure 2 Bone marrow
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2274/158194_B_4_4.jpg
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2274/158194_B_4_4.jpg
Figure 3 RNA cell line category: Group enriched (HMC-1, NB-4, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169896-ITGAM
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169896-ITGAM
Specifications
- Immunogen
- Recombinant human ITGAM (AA: 623-728) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human ITGAM
- Species Reactivity
- Human
- Clone
- 3A4B10
- Molecule Class
- Integrin
- Applications
- IHC, FC
- Conjugate
- Unconjugated
- Related Disease
- Increased risk of autoimmune diseases.
Susceptibility to infections.
Involved in the progression of certain cancers.
involved in long term pulmonary complications after COVID-19 infection
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunohistochemistry-Paraffin: 1:200 - 1:1000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
- Gene ID
- 3684
- UniProt ID
- P11215
- Long Name
- Integrin Subunit Alpha M
- Cellular Localization
- Cell membrane, Membrane raft
- Post Translation Modifications
- Glycosylation at Asn86, Asn240, Asn391, Asn469, Asn692, Asn696, Asn734, Asn801, Asn880, Asn900, Asn911, Asn940, Asn946, Asn978, Asn993, Asn1021, Asn1044, Asn1050, and Asn1075 (NX_P11215 [NX_P11215-1])
Modification sites at PhosphoSitePlus (P11215)
Glycosylation from GlyConnect ITAM_HUMAN (1411)
Glycosylation from GlyGen (P11215) 19 sites, 12 N-linked glycans (8 sites)
- Protein Refseq
- XP_006721108.1
- Function
- Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, 20008295).
It is identical with CR-3, the receptor for the iC3b fragment of the third complement component.
It probably recognizes the R-G-D peptide in C3b.
Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1.
Recommended Products
Isotype Control
Secondary Antibody
Reconstitution Buffer
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-098 | Recombinant Anti-Mouse Itgam VHH Single Domain Antibody | CA, IP, IF, FuncS | Llama VHH |
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