Anti-MAPK8 (clone W24V187) Recombinant Antibody Coupled Liposome (VS-1024-FY188)
CAT#: VS-1024-FY188
This formulation targets c-Jun N-terminal kinase 1 (JNK1), a signaling molecule involved in melanoma progression. The liposomal carrier enhances the delivery of JNK1 inhibitors or therapeutic agents to melanoma cells. Research indicates that inhibiting JNK1 can hinder cancer cell survival and proliferation. This strategy represents a novel therapeutic avenue for targeting the molecular pathways driving melanoma.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human breast
Immunohistochemical staining of human breast shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human thyroid gland
Immunohistochemical staining of human thyroid gland shows moderate cytoplamsic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69396/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12466_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107643-MAPK8
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V187
- Antibody Type
- IgG
- Antibody Host
- Rabbit
- Antibody Reactivity
- Human
- Antibody Description
- This antibody, crafted from recombinant rabbit sources, is designed to selectively bind to the JNK1 protein. JNK1, part of the mitogen-activated protein kinase (MAPK) signaling pathway, is involved in regulating cellular responses to stress and apoptosis. The specificity of this recombinant monoclonal antibody for JNK1 makes it an essential tool for investigating signaling pathways related to neurodegeneration and inflammatory diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MAPK8
- Introduction
- The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
- Alternative Names
- JNK; MAPK8; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
- Full Name
- Mitogen-Activated Protein Kinase 8
- Gene ID
- 5599
- UniProt ID
- P45983
- Sequence Similarities
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Cellular Localization
- Cytoplasm
Nucleus
Synapse
- Post Translation Modifications
- Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme.
Phosphorylated by TAOK2.
May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1.
Phosphorylated form is more concentrated at synapses than none-phosphorylated (By similarity).
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_024303847.1; XP_024303848.1; XP_047281436.1; XP_047281437.1; XP_047281438.1
- Function
- Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death.
Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.
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Related Signaling Pathways
FcεR1 Signaling Pathway
TCR Signaling Pathway
Related Diseases
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Downloadable Resources
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Datasheet
MSDS
COA
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