Anti-MUC1 Antibody-Cytokine Fusion Protein, IgG (Gatipotuzumab)-IL15 (CAT#: VS-0624-FY85)

• Target
• TA-MUC1

• Molecule Class
• IgG-IL15

• Species Reactivity
• Human

• Clone
• Gatipotuzumab

• Related Disease
• Cancer

• Cytokine 1
• IL15

• Cytokines 1 Description
• Interleukin 15 (IL-15) is a protein encoded by the IL15 gene. IL-15 is an inflammatory cytokine that is structurally similar to interleukin 2 (IL-2). Like IL-2, IL-15 binds and signals through a complex consisting of the IL-2/IL-15 receptor β chain (CD122) and the common γ chain (γ-C, CD132).

• Cytokine 1 Species
• Human

• Applications
• This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

• Alternative Names
• Mucin 1, Cell Surface Associated; Tumor-Associated Epithelial Membrane Antigen; Breast Carcinoma-Associated Antigen DF3; Peanut-Reactive Urinary Mucin; Polymorphic Epithelial Mucin; Carcinoma-Associated Mucin; Mucin 1, Transmembrane; Krebs Von Den Lungen-6; Cancer Antigen 15-3; Episialin; CA 15-3; H23AG; MUC-1; KL-6; PEMT; EMA; PUM; PEM; GT-00AxIL15

• Gene ID
• 4582

• UniProt ID
• P15941

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