Anti-MUC1 Antibody-Cytokine Fusion Protein, IgG (Gatipotuzumab)-IL15
CAT#: VS-0624-FY85
Gatipotuzumab is a humanized monoclonal antibody that recognizes a tumor-specific epitope of mucin 1 (TA-MUC1), enabling it to distinguish between tumor-MUC1 and non-tumor-MUC1 epitopes. IL-15 intricately governs the activation and proliferation of T and natural killer (NK) cells. Furthermore, IL-15 plays a crucial role in providing the necessary survival signals to sustain memory T cells even in the absence of antigen. The product is a recombinant anti-TA-MUC1-human IL-15 fusion protein, known as GT-00AxIL15. This innovative GT-00AxIL15 immunocytokine consists Fc- and Fab- part of the parental mAb GT-00A, human IL-15, N54Q mutation to remove N-glycosylation site in the Fab domain, Fc N-glycosylation site N297, K447A mutation at transition sequence to IL-15 modules to remove potential protease site; 6xPAPAP linker between IL-15 and the heavy chain.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/1789_B9_13_cr596f381e20667_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1986/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/100_E7_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8855/101_E7_1_blue_red_green.jpg
Normal Tissue
Figure 5 Stomach
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_2_1.jpg
Normal Tissue
Figure 6 Colon
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_9_3.jpg
Normal Tissue
Figure 7 Kidney
Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36/155175_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (CAPAN-2, OE19, RPTEC TERT1, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185499-MUC1
❮
❯
Specifications
- Target
- TA-MUC1
- Molecule Class
- IgG-IL15
- Species Reactivity
- Human
- Clone
- Gatipotuzumab
- Related Disease
- Cancer
- Cytokine 1
- IL15
- Cytokines 1 Description
- Interleukin 15 (IL-15) is a protein encoded by the IL15 gene. IL-15 is an inflammatory cytokine that is structurally similar to interleukin 2 (IL-2). Like IL-2, IL-15 binds and signals through a complex consisting of the IL-2/IL-15 receptor β chain (CD122) and the common γ chain (γ-C, CD132).
- Cytokine 1 Species
- Human
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
- Alternative Names
- Mucin 1, Cell Surface Associated; Tumor-Associated Epithelial Membrane Antigen; Breast Carcinoma-Associated Antigen DF3; Peanut-Reactive Urinary Mucin; Polymorphic Epithelial Mucin; Carcinoma-Associated Mucin; Mucin 1, Transmembrane; Krebs Von Den Lungen-6; Cancer Antigen 15-3; Episialin; CA 15-3; H23AG; MUC-1; KL-6; PEMT; EMA; PUM; PEM; GT-00AxIL15
- Gene ID
- 4582
- UniProt ID
- P15941
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0624-FY85. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MUC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2049-VHH | Recombinant Anti-human MUC1 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
| HPAB-AP504-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP504-YC) | FC | Camel VHH |
| HPAB-AP505-YC | Recombinant Camel Anti-MUC1 Single Domain Antibody (HPAB-AP505-YC) | ELISA | Camel VHH |
| HPAB-0736-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0736-YJ-VHH) | ELISA | Camelid VHH |
| HPAB-0737-YJ-VHH | Camelid Anti-MUC1 Recombinant Single Domain Antibody (HPAB-0737-YJ-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1077z | Mouse Anti-MUC1 Recombinant Antibody (clone 18C4) | WB, FC, IF, IHC | Mouse IgG1, κ |
| HPAB-AP738-YC | Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP738-YC) | ELISA | Mouse IgG |
| HPAB-AP739-YC | Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP739-YC) | ELISA | Mouse IgG |
| HPAB-AP740-YC | Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP740-YC) | ELISA | Mouse IgG |
| HPAB-AP741-YC | Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP741-YC) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-166 | Humanized Anti-MUC1 Recombinant Antibody (clone Cantuzumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Humanized (from mouse) IgG1, κ |
| TAB-H77 | Human Anti-MUC1 Recombinant Antibody (TAB-H77) | FuncS, Inhib | IgG1, κ |
| TAB-413MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-413MZ-F(E)) | ELISA | Humanized Fab |
| TAB-425MZ-F(E) | Anti-Human MUC1 Recombinant Antibody Fab Fragment (huDMB5F3) | FC | Humanized antibody |
| TAB-430MZ-F(E) | Anti-Human MUC1 Recombinant Antibody Fab Fragment (BLC595) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L036E | anti-MUC1 immunotoxin C242 (Fab)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L064E | anti-MUC1 immunotoxin H23 (scFv)-PE | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-656 | Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment | WB, IF, FuncS | Mouse scFv |
| FAMAB-0225-YC-S(P) | Mouse Anti-MUC1 Recombinant Antibody (clone MUSE11); scFv Fragment | IHC | Mouse scFv |
| HPAB-0872LY-S(P) | Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0872LY-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0873LY-S(P) | Human Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0873LY-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0874LY-S(P) | Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (HPAB-0874LY-S(P)) | ELISA, WB, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0388CL-F(E) | Mouse Anti-Human MUC1 Recombinant Antibody Fab Fragment | WB, IHC | |
| TAB-437MZ | Mouse Anti-MUC1 Recombinant Antibody (TAB-437MZ) | FC, ELISA | Mouse IgG |
| TAB-438MZ | Mouse Anti-MUC1 Recombinant Antibody (TAB-438MZ) | FC, ELISA | Mouse IgG |
| TAB-439MZ | Anti-Human MUC1 Recombinant Antibody (1B2) | FC | |
| PABX-183-F (E) | Recombinant Mouse Anti-MUC1 Antibody Fab Fragment (CTM01) | Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-412MZ | Human Anti-MUC1 Recombinant Antibody (TAB-412MZ) | ELISA | Chimeric (mouse/human) IgG |
| TAB-412MZ-S(P) | Mouse Anti-MUC1 Recombinant Antibody; scFv Fragment (TAB-412MZ-S(P)) | ELISA | Mouse scFv |
| TAB-412MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-412MZ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-431MZ-F(E) | Anti-Human MUC1 Recombinant Antibody Fab Fragment (PH1) | ELISA, WB, FC, IHC | Human antibody |
| TAB-432MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-432MZ-F(E)) | ELISA, FC | Human Fab |
| TAB-433MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-433MZ-F(E)) | ELISA, FC | Human Fab |
| TAB-434MZ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (TAB-434MZ-F(E)) | ELISA, FC | Human Fab |
| PABX-143 | Recombinant Human Anti-MUC1 Antibody (CTM01) | WB, ELISA, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-012LC | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) | ELISA, FC, IHC | Humanized antibody |
| Gly-120LC | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-012LC-1 | Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) | ELISA, FC, IHC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-109LC | Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-121LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| Gly-122LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| Gly-124LC | Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0379MZ | Chicken Anti-MUC1 Polyclonal IgY | IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC054 | PE-A*02:01/Human MUC1 (LLLTVLTVV) MHC Tetramer | FCM | |
| MHC-LC781 | A*0201/Human MUC-1 (LLLLTVLTV) MHC Tetramer | FCM | |
| MHC-LC1950 | PE-A2/Human MUC1 (NLTISDVSV) MHC Tetramer | FCM | |
| MHC-YF272 | A*02:01/Human MUC1 (LLLLTVLTV) MHC Monomer | MHC Multimer | |
| MHC-YF570 | A*02:01/Human Mucin (TLAPATEPA) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2320 | Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB) | IHC-P, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0838LC | Recombinant Mouse Anti-Human MUC1 Antibody (SM3) | ELISA | IgG1 |
| EPAF-0581CQ | Recombinant Mouse Anti-Human MUC1 Antibody (B27.29) | Neut, FC | IgG1 |
| EPAF-0583CQ | Recombinant Mouse Anti-Human MUC1 Antibody (BC4E549) | Neut, FC | IgG1 |
| EPAF-0584CQ | Recombinant Mouse Anti-Human MUC1 Antibody (DF3) | Neut, FC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0272CQ-F(E) | Human Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-0272CQ-F(E)) | ELISA, FC, FuncS | Human Fab |
| HPAB-AP738-YC-F(E) | Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-AP738-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-AP739-YC-F(E) | Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-AP739-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-AP740-YC-F(E) | Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-AP740-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-AP741-YC-F(E) | Mouse Anti-MUC1 Recombinant Antibody; Fab Fragment (HPAB-AP741-YC-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H56 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H56) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-H65 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H65) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-026ML | Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-026ML) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-166 | Afuco™ Anti-MUC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-166) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-H77 | Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77) | ELISA, FC, IP, FuncS, IF | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP745-YC | Mouse Anti-MUC1 Recombinant Antibody (HPAB-AP745-YC) | ELISA | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY192 | AbPlus™ Anti-MUC1 Magnetic Beads (139H2) | IP, Protein Purification | |
| VS-0724-YC1494 | AbPlus™ Anti-MUC1 Magnetic Beads (VS-0724-YC1494) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY26 | Human Anti-MUC1 (clone 1B2) scFv-Fc Chimera | FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY169 | CytoStream™ Mouse Anti-MUC1 Recombinant Antibody (VS-0225-XY169) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1394 | Anti-MUC1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4575 | Anti-Human MUC1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4576 | Anti-Mouse MUC1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC379 | Recombinant Anti-MUC1 Vesicular Antibody, EV Displayed (VS-0425-YC379) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC131 | Recombinant Anti-MUC1 Biparatopic Antibody, Tandem scFv | ELISA, IHC | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
-2-1.png)
Application: ELISA
Application: ELISA, FC
Application: ELISA, IHC, FC, IP, IF, FuncS
-3.jpg)
Application: Neut
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: Neut, IHC, Activ, FuncS, IF, ELISA
Application: ELISA, FC
-3.jpg)
Application: IB, FC, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
