Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (3A7)-IFNA17 (CAT#: ACFP-CQ2308)

• Target
• PD-L1

• Molecule Class
• IgG-IFNA17

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• 3A7

• Cytokine 1
• IFNA17

• Cytokines 1 Description
• IFNA17 (Interferon Alpha 17) is a Protein Coding gene. Diseases associated with IFNA17 include Adenosquamous Pancreas Carcinoma and Crimean-Congo Hemorrhagic Fever. Among its related pathways are Cytokine Signaling in Immune system and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA10.

• Cytokine 1 Species
• Human

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.

• Alternative Names
• CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1

• Gene ID
• 29126

• UniProt ID
• Q9NZQ7

• ACFP-CQ0035
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