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BTK
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (granulocytes, B-cells, monocytes, Kupffer cells, Macrophages, Hofbauer cells, Plasma cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (Daudi, HEL, HMC-1, U-937)
Interaction
Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with ARID3A, CAV1, FASLG, PIN1, TLR8 and TLR9.
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
Related Signaling Pathways
BCR Signaling Pathway
Related Diseases
Primary Immunodeficiency
- Rabbit Anti-BTK Recombinant Antibody (clone CBACN-597) (MRO-2304-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC
- Mouse Anti-BTK Recombinant Antibody (clone 4j6) (MOB-1492MZ)
-
- Species Reactivity: Human
- Type: Mouse IgG3
- Application: IP, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, FC, ICC, IF, IHC
- Rabbit Anti-BTK Recombinant Antibody (clone CBACN-075) (MRO-0196-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human, Monkey
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, ICC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
- Recombinant Mouse Anti-BTK Antibody (VS-0923-FY24) (VS-0923-FY24)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB
- Rabbit Anti-BTK Recombinant Antibody (VS3-WK886) (VS3-WK886)
-
- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.