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    Anti-BTK Products

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    For Research Use Only. Not For Clinical Use.


    Creative Biolabs presents an unmatched array of anti-BTK recombinant antibody products designed to accelerate your research and therapeutic endeavors. Harnessing the latest in antibody engineering and production technologies, our anti-BTK antibodies exhibit superior specificity and affinity, making them ideal for advanced immunological studies and therapeutic applications. At the same time, our products are meticulously validated to ensure optimal performance in various assays to achieve your projects with efficacy and accuracy.

    BTK: A Potential Therapeutic Target for Autoimmune Diseases and B Cell Malignancies

    BTK, a critical tyrosine kinase for B cell function, serves as a central signaling node, integrating signals from the BCR, chemokine receptors, and TLR. Through direct interactions with five distinct molecules, BTK facilitates B cell proliferation, antibody production, and pro-inflammatory cytokine secretion, influencing B cell adhesion, migration, and the tumor microenvironment. Given its pivotal role in these physiological processes, BTK has emerged as a promising therapeutic target for autoimmune diseases and B cell-related malignancies.

    Alternative Names

    B-Cell Progenitor Kinase; Bruton Agammaglobulinemia Tyrosine Kinase; EC 2.7.10.2; EC 2.7.10; Agammaglobulinaemia Tyrosine Kinase; AGMX1; BPK; ATK; IMD1; Truncated Bruton Agammaglobulinemia Tyrosine Kinase; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17); Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14); Agammaglobulinemia Tyrosine Kinase; Bruton Tyrosine Kinase; PSCTK1; XLA; AT.

    Background

    The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Protein class

    Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (granulocytes, B-cells, monocytes, Kupffer cells, Macrophages, Hofbauer cells, Plasma cells)

    Immune cell specificity

    Immune cell enriched (basophil)

    Cell line specificity

    Cell line enhanced (Daudi, HEL, HMC-1, U-937)

    Interaction

    Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with ARID3A, CAV1, FASLG, PIN1, TLR8 and TLR9.

    Molecular function

    Kinase, Transferase, Tyrosine-protein kinase

    More Types Infomation

    Anti-BTK rAb Products

    Creative Biolabs offers a comprehensive selection of anti-BTK recombinant antibody products designed to target and inhibit BTK. These high-affinity and specific antibodies are available in various formats, including mouse and rabbit derivations, and are applicable for a range of experimental techniques such as Western Blot, Immunoprecipitation, ELISA, Immunohistochemistry, and Immunofluorescence. Engineered to support both research and therapeutic applications, Creative Biolabs’ anti-BTK recombinant antibodies are valuable tools for advancing studies in immunology, cancer, and related fields.

    Table 1. Featured anti-BTK recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    MRO-2304-CN Rabbit Anti-BTK Recombinant Antibody (clone CBACN-597) Human Rabbit IgG WB, IP
    MRO-0196-CN Rabbit Anti-BTK Recombinant Antibody (clone CBACN-075) Human Rabbit IgG WB, IP
    MOB-2243z Mouse Anti-BTK Recombinant Antibody (clone 21F12) Human Mouse IgG2b WB, FC, ICC, IF, IHC
    VS3-WK2119 Rabbit Anti-BTK (pY223) Recombinant Antibody (clone R09-4V4) Human Rabbit IgG WB, IP
    VS-0923-FY24 Recombinant Mouse Anti-BTK Antibody Human Mouse IgG2a ELISA, WB

    Creative Quality Control

    Creative Biolabs is dedicated to providing superior anti-BTK recombinant antibodies. Our unwavering commitment to quality is demonstrated by our state-of-the-art manufacturing facilities and stringent quality control protocols. Each antibody undergoes rigorous validation to ensure exceptional specificity, affinity, and purity. Our team of industry experts continually monitors and optimizes production processes to maintain the highest standards in biotechnology.

    Fig.1 IHC analysis. (Creative Biolabs Original)Fig.1 IHC analysis of anti-BTK antibody
    (Cat# ZG-0103U, Creative Biolabs).

    Fig.2 WB analysis. (Creative Biolabs Original)Fig.2 WB analysis of anti-BTK antibody
    (Cat# ZG-0353F, Creative Biolabs).

    Fig.3 IHC analysis. (Creative Biolabs Original)Fig.3 IHC analysis of anti-BTK antibody
    (Cat# ZG-0353F, Creative Biolabs).

    Fig.4 IF analysis. (Creative Biolabs Original)Fig.4 IF analysis of anti-BTK antibody
    (Cat# ZG-0353F, Creative Biolabs).

    Fig.5 WB analysis. (Creative Biolabs Original)Fig.5 WB analysis of anti-BTK antibody
    (Cat# ZG-0354F, Creative Biolabs).

    Fig.6 IP analysis. (Creative Biolabs Original)Fig.6 IP analysis of anti-BTK antibody
    (Cat# ZG-0354F, Creative Biolabs).

    Customer Reviews

    Excellent
    Wh***e
    Mouse Anti-BTK Recombinant Antibody (clone 21F12) (MOB-2243z)
    I've been using this Mouse Anti-BTK Recombinant Antibody in my research, and I'm extremely impressed with its performance. The antibody consistently delivers strong, specific signals in my Western blotting experiments. The high sensitivity allows me to detect even low levels of BTK expression, which is crucial for my research. Additionally, the antibody is highly specific and doesn't cross-react with other proteins, ensuring reliable results. The overall quality and performance of this antibody have been exceptional. I would highly recommend it to anyone working with BTK research.
    17/Nov/2021
    Excellent
    Ad***m
    Recombinant Mouse Anti-BTK Antibody (VS-0923-FY24) (VS-0923-FY24)
    This BTK antibody has been a total game-changer for my research! It's super sensitive and picks up even the tiniest amounts of BTK. Plus, it's super specific, so I don't have to worry about any cross-reactivity. I've been using it for Western blotting, and the results have been consistently awesome. If you're working with BTK, this antibody is a must-have!
    11/May/2022
    Excellent
    Ta***y
    Hi-Affi™ Rabbit Anti-BTK Recombinant Antibody (clone DS393AB) (MOR-0393)
    The Hi-Affi™ BTK antibody has consistently exceeded my expectations in recent months. The high affinity and specificity have been invaluable for my research. I've used it for immunocytochemistry assay and ELISA assay, and it consistently delivers excellent results. The low background staining has been a huge plus, making it easy to interpret my data. If you're looking for a reliable and high-quality BTK antibody, I highly recommend this one.
    11/Oct2023

    rAb Production

    Our advanced anti-BTK recombinant antibody platform employs genetically engineered cells to produce high-quality antibodies targeting the BTK protein. This innovative approach enables scalable and efficient antibody production, ensuring a consistent supply for research and therapeutic applications.

    Featured Anti-BTK Recombinant Antibody Production PlatformsFig.7 Milligram-scale. (Creative Biolabs Original)
    Fig.7 Milligram-scale anti-BTK recombinant antibody production.

    Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-BTK recombinant antibody production.

    rAb Modalities

    Creative Biolabs offers a wide range of high-quality anti-BTK recombinant antibodies in various formats, designed to meet the diverse needs of researchers.

    Fig.9 BTK antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-BTK recombinant antibody production and modalities.

    Public Drug Information Targeting BTK

    Table 2. Public drug targeting BTK.

    Highest Phase Mechanism of Action Product Category Condition Organization
    Phase II Bruton's Tyrosine Kinase (BTK) Inhibitors
    Glucagon Receptor (GCGR) Agonists
    Glucagon-Like Peptide 1 Receptor (GLP1R) Agonists
    Signal Transduction Modulators     		Fc Fusion Proteins
    Glucagon-Like Peptide 1 (GLP-1) Analogues
    Pegylated Drugs
    Polypeptides, from 41 AA     		Diabetes type 2
    Hyperlipidemia
    Non-alcoholic fatty liver disease (NAFLD)
    Non-alcoholic steatohepatitis (NASH)
    Obesity     		Hanmi (Originator)
    Janssen Pharmaceuticals (Janssen)
    Janssen Research & Development (Janssen)
    Merck & Co
    Merck & Co. (Merck & Co)
    Preclinical Stem Cell-Based Gene Therapy Agammaglobulinemia, X-linked (Bruton syndrome) Seattle Children's Hospital (Originator)
    Preclinical Gene Therapy
    Lentiviral Vectors     		Agammaglobulinemia, X-linked (Bruton syndrome) University of Washington (Originator)
    Biological Testing Angiogenesis Inhibitors
    Bcr-Abl (Bcr-Abl1) Kinase Inhibitors
    Bruton's Tyrosine Kinase (BTK) Inhibitors
    Discoidin Domain-Containing Receptor 1 (DDR1) Inhibitors
    Discoidin Domain-Containing Receptor 2 (DDR2) Inhibitors
    Ephrin (EPH) Receptor Inhibitors
    KIT (c-KIT) (Leu576Pro Mutant) Inhibitors
    Macrophage Colony-Stimulating Factor 1 Receptor (CSF1R; CD115; c-Fms) Inhibitors
    Mast/Stem Cell Growth Factor Receptor Kit (KIT; c-KIT; CD117) Inhibitors
    PDGFRalpha Inhibitors
    Platelet-Derived Growth Factor Receptor beta (PDGFRB) Inhibitors
    Proto-Oncogene Tyrosine-Protein Kinase Src (SRC; SRC1) Inhibitors
    Signal Transduction Modulators
    Tyrosine Protein Kinase Blk Inhibitors
    Tyrosine-Protein Kinase ABL1 (ABL) Inhibitors
    Tyrosine-Protein Kinase CSK Inhibitors
    Tyrosine-Protein Kinase Fgr Inhibitors
    Tyrosine-Protein Kinase FRK Inhibitors
    Tyrosine-Protein Kinase Fyn Inhibitors
    Tyrosine-Protein Kinase HCK Inhibitors
    Tyrosine-Protein Kinase Lck Inhibitors
    Tyrosine-Protein Kinase Lyn Inhibitors
    Tyrosine-Protein Kinase Yes (YES1) Inhibitors     		Nanoparticles
    Peptide-Drug Conjugates     		Cancer Cornell University
    Memorial Sloan-Kettering Cancer Center
    Biological Testing Bruton's Tyrosine Kinase (BTK) Inhibitors
    Signal Transduction Modulators     		Oligonucleotides
    Small Interfering RNA (SiRNAs)     		Cancer, breast City University of New York (CUNY) (Originator)

    (Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

    BTK-Targeted Drug Information

    Table 3. Therapeutic approaches targeting BTK in clinical development.

    Highest Phase Mechanism of Action Product Category Condition Organization
    Preclinical Gene Therapy
    Lentiviral Vectors     		Agammaglobulinemia, X-linked (Bruton syndrome) Lonza (Originator)
    Biological Testing Bruton's Tyrosine Kinase (BTK) Degradation Inducers
    Drugs Targeting Protein Cereblon (CRBN)
    Signal Transduction Modulators     		Pegylated Drugs
    PROTACs (Proteolysis Targeting Chimeras)     		Cancer Novartis (Originator)
    Biological Testing Bruton's Tyrosine Kinase (BTK) Degradation Inducers
    Drugs Targeting Protein Cereblon (CRBN)
    Signal Transduction Modulators     		Pegylated Drugs
    PROTACs (Proteolysis Targeting Chimeras)     		Cancer Novartis (Originator)
    Biological Testing Bruton's Tyrosine Kinase (BTK) Degradation Inducers
    Drugs Targeting Protein Cereblon (CRBN)
    Signal Transduction Modulators     		Pegylated Drugs
    PROTACs (Proteolysis Targeting Chimeras)     		Cancer Novartis (Originator)
    Biological Testing Angiogenesis Inhibitors
    Bcr-Abl (Bcr-Abl1) Kinase Inhibitors
    Bruton's Tyrosine Kinase (BTK) Inhibitors
    Discoidin Domain-Containing Receptor 1 (DDR1) Inhibitors
    Discoidin Domain-Containing Receptor 2 (DDR2) Inhibitors
    Ephrin (EPH) Receptor Inhibitors
    KIT (c-KIT) (Leu576Pro Mutant) Inhibitors
    Macrophage Colony-Stimulating Factor 1 Receptor (CSF1R; CD115; c-Fms) Inhibitors
    Mast/Stem Cell Growth Factor Receptor Kit (KIT; c-KIT; CD117) Inhibitors
    PDGFRalpha Inhibitors
    Platelet-Derived Growth Factor Receptor beta (PDGFRB) Inhibitors
    Proto-Oncogene Tyrosine-Protein Kinase Src (SRC; SRC1) Inhibitors
    Signal Transduction Modulators
    Tyrosine Protein Kinase Blk Inhibitors
    Tyrosine-Protein Kinase ABL1 (ABL) Inhibitors
    Tyrosine-Protein Kinase CSK Inhibitors
    Tyrosine-Protein Kinase Fgr Inhibitors
    Tyrosine-Protein Kinase FRK Inhibitors
    Tyrosine-Protein Kinase Fyn Inhibitors
    Tyrosine-Protein Kinase HCK Inhibitors
    Tyrosine-Protein Kinase Lck Inhibitors
    Tyrosine-Protein Kinase Lyn Inhibitors
    Tyrosine-Protein Kinase Yes (YES1) Inhibitors     		Oligopeptides, less than 10 AA
    Peptide-Drug Conjugates
    RGD peptides     		Cancer Inner Mongolia Medical University (Originator)

    (Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

    If you want to know more about our high-quality anti-BTK recombinant products, please feel free to contact us.

    Related Signaling Pathways
    BCR Signaling Pathway BCR Signaling Pathway
    Related Diseases
    Primary Immunodeficiency Primary Immunodeficiency
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