FOLR1
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG2a
Application: WB, ELISA, FC, ICC, IF, IHC
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Derivation: Phage display library
Species Reactivity: Human
Type: Rabbit IgG
Application: WB
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Species Reactivity: Human
Application: FC, ICC/IF, IHC-Fr, IP, WB
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Species Reactivity: Human
Type: Mouse IgG2a
Application: FC, IHC, WB, IP
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Species Reactivity: Human, Cynomolgus monkey
Type: Human antibody
Application: IHC
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Target: FOLR1
Linker: sulfo-SPDB (sulfosuccinimidyl N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
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Target: FRα
Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Derivation: Humanized
Species Reactivity: Human, Cynomolgus
Type: Human IgG1, κ
Application: ELISA, WB, IHC
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Derivation: Chimeric (Rat/Human)
Species Reactivity: Human, Cynomolgus
Type: Chimeric (Rat/Human) IgG1, κ
Application: ELISA, WB, IHC
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Species Reactivity: Human, Cynomolgus
Type: Rat IgG1, κ
Application: ELISA, WB, IHC
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, FC, WB
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Species Reactivity: Human, Cynomolgus
Type: Human scFv
Application: ELISA, WB, IHC
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Species Reactivity: Human, Cynomolgus
Type: Rat scFv
Application: ELISA, WB, IHC
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Species Reactivity: Human
Type: Human scFv
Application: ELISA, FC, WB
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Target: folate receptor (FR)
Linker: disulfide ("S-S") linker
Drug: doxorubicin
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Target: FRα
Linker: maleimide containing linkers
Drug: DGN462
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Species Reactivity: Human, Cynomolgus
Type: Rat Fab
Application: ELISA, WB, IHC
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, FC, WB
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Target: α-FR
Species Reactivity: Human
Cytokine 1: IL2
Host: Chimeric (Human-Mouse)
Cytokine 1 Species: Human
Molecule Class: IL2-scFv
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Derivation: Humanized (from mouse)
Species Reactivity: Human
Type: IgG1 - kappa
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
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For Research Use Only. Not For Clinical Use.