FOLR1
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IHC, WB, IP
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- Species Reactivity: Human
- Application: FC, ICC/IF, IHC-Fr, IP, WB
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- Target: FOLR1
- Linker: sulfo-SPDB (sulfosuccinimidyl N-succinimidyl-4-(2-pyridyldithio)butyrate)
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, IHC, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: FuncS
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, FC, IHC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FuncS
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, IHC, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, IHC, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IHC, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, IHC, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, IHC, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, IHC, FC
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- Species Reactivity: human
- Type: scFv-Tat
- Application: WB, ICC, Neut, FuncS
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, IHC, FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, IHC, FC
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- Species Reactivity: human
- Type: scFv-(+36GFP)
- Application: WB, Neut, FuncS
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- Derivation: Humanized (mouse/human)
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, IHC
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- Derivation: Humanized (mouse/human)
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC
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- Species Reactivity: human
- Type: scFv-(D-Arg)9
- Application: PCA, Neut, FuncS
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- Target: FOLR1
- Linker: sulfo-SPDB
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Target: FRα
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, WB
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, WB
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Human antibody
- Application: IHC
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Human scFv
- Application: ELISA, WB, IHC
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Human IgG1, κ
- Application: ELISA, WB, IHC
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- Species Reactivity: Human, Cynomolgus
- Type: Human scFv
- Application: ELISA, WB, IHC
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- Derivation: Chimeric (Rat/Human)
- Species Reactivity: Human, Cynomolgus
- Type: Chimeric (Rat/Human) IgG1, κ
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, WB, IHC
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- Species Reactivity: Human, Cynomolgus
- Type: Rat scFv
- Application: ELISA, WB, IHC
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- Species Reactivity: Human, Cynomolgus
- Type: Rat IgG1, κ
- Application: ELISA, WB, IHC
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- Derivation: Humanized (mouse/human)
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: FC, IP, ELISA, Neut, FuncS, IF
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
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- Target: folate receptor (FR)
- Linker: disulfide ("S-S") linker
- Drug: doxorubicin
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, IHC, WB
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- Target: FRα
- Linker: maleimide containing linkers
- Drug: DGN462
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, IHC, WB
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC, IHC, WB
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Humanized Fab
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC, WB
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- Derivation: Chimeric (Rat/Human)
- Species Reactivity: Human, Cynomolgus
- Type: Chimeric (Rat/Human) Fab
- Application: ELISA, WB, IHC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human, Cynomolgus
- Type: Rat Fab
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, IHC, WB
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- Target: α-FR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Chimeric (Human-Mouse)
- Cytokine 1 Species: Human
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Human antibody
- Application: IHC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, IHC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Human antibody
- Application: IHC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1
- Application: ELISA, FC, IHC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, IHC, WB
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