Anti-CD20 Antibody-Cytokine Fusion Protein, scFv-Fc-IL2
CAT#: ACFP-SH133
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD20 scFv-Fc to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD20 as well as the biological activity of IL2. This antibody-Fc-hIL2 was at least equivalent to the commercial molecule in both binding to Daudi cells and activation of ADCC and may represent a promising plant-derived biopharmaceutical for the treatment of NHLs. This immunocytokine was designed for treating leukemias, lymphomas, rheumatoid arthritis, and other autoimmune diseases.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
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Specifications
- Target
- CD20
- Molecule Class
- scFv-Fc-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- Rituximab
- Related Disease
- Leukemias, Lymphomas, Rheumatoid arthritis, and other autoimmune diseases
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- MS4A1; membrane-spanning 4-domains; subfamily A; member 1; B1; S7; Bp35; CD20; CVID5; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
- Gene ID
- 931
- UniProt ID
- A0A024R507
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Datasheet
MSDS
COA
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Lot Number:
See other products for "Clone Rituximab"
- CAT
- Product Name
See other products for "MS4A1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-207 | Anti-Human CD20 Recombinant Antibody | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| TAB-1671CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1671CL-S(P)) | CDC | Mouse scFv |
| TAB-1675CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1675CL-S(P)) | ELISA, WB | Mouse scFv |
| TAB-1692CL-S(P) | Anti-Human MS4A1 Recombinant Antibody scFv Fragment (Zytux) | ELISA, WB | Chimeric antibody (mouse/human) |
| PABX-026-F (E) | Recombinant Mouse Anti-CD20 Antibody Fab Fragment (C2H7) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-422 | Human Anti-MS4A1 Recombinant Antibody (clone 2F2) | WB, ELISA, FuncS | Human IgG1,κ |
| PABL-423 | Mouse Anti-MS4A1 Recombinant Antibody (clone GA101) | FC, Activ, Agonist, IF, WB, Cyt, FuncS | Mouse IgG |
| HPAB-0346-WJ | Human Anti-MS4A1 Recombinant Antibody (clone 7F2) | ELISA | Humanized IgG |
| HPAB-0347-WJ | Human Anti-MS4A1 Recombinant Antibody (clone 8G3) | ELISA | Humanized IgG |
| HPAB-0138-WJ | Human Anti-MS4A1 Recombinant Antibody (clone L4H7) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0001CL | Human Anti-MS4A1 Recombinant Antibody (TAB-0001CL) | ELISA, ADCC, CDC | Human IgG |
| TAB-1645CL | Anti-Human MS4A1 Recombinant Antibody (2.1.2) | Cyt, FuncS | Fully human antibody |
| TAB-1646CL | Anti-Human MS4A1 Recombinant Antibody (1.1.2) | Cyt, FuncS | Fully human antibody |
| TAB-1647CL | Anti-Human MS4A1 Recombinant Antibody (1.5.3) | Cyt, FuncS | Fully human antibody |
| TAB-1648CL | Anti-MS4A1 Recombinant Antibody (MEDI-552) | Inhib |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1635CL | Anti-Human MS4A1 Recombinant Antibody (BVX20) | Inhib | Humanized antibody |
| TAB-1636CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL) | ADCC, CDC | Humanized IgG |
| TAB-1637CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL) | ADCC, CDC | Humanized IgG |
| TAB-1638CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL) | ADCC, CDC | Humanized IgG |
| TAB-1639CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL) | ADCC, CDC, Apop | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1632CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1F5) | FC | |
| TAB-1657CL-F(E) | Mouse Anti-MS4A1 Recombinant Antibody Fab Fragment (TAB-1657CL-F(E)) | Apop, FuncS | |
| TAB-1658CL-F(E) | Mouse Anti-MS4A1 Recombinant Antibody Fab Fragment (TAB-1658CL-F(E)) | Apop, FuncS | |
| TAB-1659CL-F(E) | Mouse Anti-MS4A1 Recombinant Antibody Fab Fragment (TAB-1659CL-F(E)) | Apop, FuncS | |
| TAB-007ML | Anti-Canine MS4A1 Recombinant Antibody (TAB-007ML) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-059LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-063LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
| Gly-097LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-115LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-138LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-063LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
| Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-158LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC066 | PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC067 | APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC068 | BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
| MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0144-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone C2B8); Fab Fragment | WB, ELISA | Chimeric (mouse/human) Fab |
| HPAB-0247-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody Fab Fragment (HPAB-0247-FY-F(E)) | Inhib, ELISA | Humanized Fab |
| HPAB-0382-WJ-F(E) | Goat Anti-MS4A1 Recombinant Antibody (clone TG20); Fab Fragment | ELISA | Goat Fab |
| HPAB-N0180-YC-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-N0180-YC-F(E)) | FC | Human Fab |
| HPAB-N0181-YC-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone OFA); Fab Fragment | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-FY-S(P) | Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0018-FY-S(P)) | FC | Humanized scFv |
| HPAB-0021-FY-S(P) | Human Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-0021-FY-S(P)) | FC | Humanized scFv |
| HPAB-652-FY-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-652-FY-S(P)) | FC | Mouse scFv |
| HPAB-0614-WJ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0614-WJ-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0615-WJ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0615-WJ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0704-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0704-YC) | ELISA, FuncS | Camelid VHH |
| HPAB-M0705-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0705-YC) | ELISA | Camelid VHH |
| HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC) | ELISA | Camelid VHH |
| HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0707-YC) | ELISA | Camelid VHH |
| HPAB-M0708-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0708-YC) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-772 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-016 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-016) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-028 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY188 | AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC138 | Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced | FC, CDC, IP | Antibody hexamer |
| VS-0924-YC139 | Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced | FC, Activ, Agonist, IF, WB, Cyt, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY85 | Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY30 | Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera | FuncS | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY168 | CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC513 | Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4510 | Anti-MS4A1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4511 | Anti-Mouse MS4A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC129 | Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv | ELISA, FC | Tandem scFv |
| VS-0525-YC222 | Recombinant Anti-MS4A1 Biparatopic Antibody, Tandem scFv | ELISA, IF, WB | Tandem scFv |
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