Anti-MS4A1 Antibody-Cytokine Fusion Protein, IgG-IL2no-alpha

Name: Anti-MS4A1 Antibody-Cytokine Fusion Protein, IgG-IL2no-alpha
SKU: VS-0624-FY104
Rating: 5 (1 reviews)

CAT#: VS-0624-FY104

This is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of immune system B cells. IFNB1 is more potent than interferon-α (IFN-α) in inducing apoptotic and antiproliferative pathways required for controlling tumor cell growth. Diseases associated with IFNB1 include multisystem inflammatory syndrome in children and secondary progressive multiple sclerosis. The antibody-IL2no-alpha Immunocytokine is specific for the human CD20 molecule and the sequences of its variable regions are those of antibody. The light chain is formed by a VL variable region and a C kappa mouse constant region. The heavy chain is made up of the VH variable region, followed by a constant region of mouse IgG2a that has a connecting peptide (Gly4Ser)3ThrGly fused to the carboxyl terminus and then the IL2no-alpha molecule.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

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Specifications

Target
CD20

Molecule Class
IgG-IL2no-alpha

Species Reactivity
Human

Clone
Rituximab

Related Disease
Autoimmune disease

Cytokine 1
IL2no-alpha

Cytokines 1 Description
IL-2 is a cytokine that plays a key role in controlling immune system homeostasis, acting on both effector and regulatory lymphocytes. IL-2 binds to multimeric IL-2 receptors (IL-2R) expressed on different lymphocyte subsets and induces lymphocyte survival, proliferation, and activation. No-alpha mutant protein is an agonist with greater antitumor activity than wtIL-2 but less toxicity.

Cytokine 1 Species
Human

Applications
This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Introduction
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

Alternative Names
Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1

Gene ID
931

UniProt ID
P11836

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Datasheet

Datasheet - VS-0624-FY104.pdf

MSDS

MSDS - VS-0624-FY104.pdf

COA

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TAB-1633CL-S(P)	Anti-Human MS4A1 Recombinant Antibody scFv Fragment (ch1F5)	FC	Chimeric antibody (mouse/human)
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
Gly-142LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody

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Gly-155LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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MOR-2295	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB)	IHC-Fr, IHC-P	Rabbit IgG
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HPAB-0018-FY-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0018-FY-F(E))	FC	Humanized Fab
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VS-0924-YC138	Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced	FC, CDC, IP	Antibody hexamer
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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