Anti-MS4A1 Antibody-Cytokine Fusion Protein, IgG-mIFNβ

Name: Anti-MS4A1 Antibody-Cytokine Fusion Protein, IgG-mIFNβ
SKU: VS-0624-FY100
Rating: 5 (1 reviews)

CAT#: VS-0624-FY100

Rituximab is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of immune system B cells. IFNB1 is more potent than interferon-α (IFN-α) in inducing apoptotic and antiproliferative pathways required for controlling tumor cell growth. Diseases associated with IFNB1 include multisystem inflammatory syndrome in children and secondary progressive multiple sclerosis. The anti-CD20-mIFNβ fusion protein was generated by linking mouse IFNβ to the C-terminus of the human IgG1 CH3 domain via a SGGGGS linker. Anti-CD20-IFNβ fusion protein fuses IFNβ with anti-CD20 monoclonal antibody to achieve targeted delivery of IFNβ to B cell lymphoma cells, thereby improving the therapeutic effect.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

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Specifications

Target
CD20

Molecule Class
IgG-mIFNβ

Species Reactivity
Human

Clone
Rituximab

Related Disease
Autoimmune disease

Cytokine 1
IFNβ

Cytokines 1 Description
Interferon beta (IFNβ) is a cytokine that is naturally produced by the immune system in response to biological and chemical stimuli. It signals by binding to the heterodimeric type I IFN receptor, composed of the IFNAR1 and IFNAR2 chains, and regulates the expression of a large number of genes through classical JAK/STAT and other pathways. IFNβ has pleiotropic effects as it exerts antiviral, antiproliferative, and immunomodulatory activities on a variety of cell types. These biological activities underlie the mechanism by which this protein is used to treat a variety of diseases, such as hepatitis C infection and multiple sclerosis.

Cytokine 1 Species
Mouse

Applications
This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Introduction
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

Alternative Names
Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1

Gene ID
931

UniProt ID
P11836

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Datasheet

Datasheet - VS-0624-FY100.pdf

MSDS

MSDS - VS-0624-FY100.pdf

COA

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CAT	Product Name	Application	Type
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TAB-1670CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1670CL-F(E))	CDC	Chimeric (mouse/human) Fab
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TAB-1632CL	Anti-Human MS4A1 Recombinant Antibody (1F5)	FC
TAB-1657CL	Mouse Anti-MS4A1 Recombinant Antibody (TAB-1657CL)	Apop, FuncS
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TAB-1637CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL)	ADCC, CDC	Humanized IgG
TAB-1638CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL)	ADCC, CDC	Humanized IgG
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TAB-1645CL	Anti-Human MS4A1 Recombinant Antibody (2.1.2)	Cyt, FuncS	Fully human antibody
TAB-1646CL	Anti-Human MS4A1 Recombinant Antibody (1.1.2)	Cyt, FuncS	Fully human antibody
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Gly-059LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
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Gly-142LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody
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Gly-063LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-135LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-136LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-137LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-138LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-142LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody

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Gly-155LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Humanized antibody

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HPAB-1322-FY	Human Anti-MS4A1 Recombinant Antibody (HPAB-1322-FY)	FC, ELISA	Human IgG
HPAB-1323-FY	Human Anti-MS4A1 Recombinant Antibody (HPAB-1323-FY)	FC, ELISA	Human IgG
HPAB-1324-FY	Human Anti-MS4A1 Recombinant Antibody (HPAB-1324-FY)	FC, ELISA	Human IgG
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VS-0924-YC138	Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced	FC, CDC, IP	Antibody hexamer
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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