Anti-MS4A1 Antibody-Cytokine Fusion Protein, IgG-mIFNβ

Name: Anti-MS4A1 Antibody-Cytokine Fusion Protein, IgG-mIFNβ
SKU: VS-0624-FY100
Rating: 5 (1 reviews)

CAT#: VS-0624-FY100

Rituximab is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of immune system B cells. IFNB1 is more potent than interferon-α (IFN-α) in inducing apoptotic and antiproliferative pathways required for controlling tumor cell growth. Diseases associated with IFNB1 include multisystem inflammatory syndrome in children and secondary progressive multiple sclerosis. The anti-CD20-mIFNβ fusion protein was generated by linking mouse IFNβ to the C-terminus of the human IgG1 CH3 domain via a SGGGGS linker. Anti-CD20-IFNβ fusion protein fuses IFNβ with anti-CD20 monoclonal antibody to achieve targeted delivery of IFNβ to B cell lymphoma cells, thereby improving the therapeutic effect.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

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Specifications

Target
CD20

Molecule Class
IgG-mIFNβ

Species Reactivity
Human

Clone
Rituximab

Related Disease
Autoimmune disease

Cytokine 1
IFNβ

Cytokines 1 Description
Interferon beta (IFNβ) is a cytokine that is naturally produced by the immune system in response to biological and chemical stimuli. It signals by binding to the heterodimeric type I IFN receptor, composed of the IFNAR1 and IFNAR2 chains, and regulates the expression of a large number of genes through classical JAK/STAT and other pathways. IFNβ has pleiotropic effects as it exerts antiviral, antiproliferative, and immunomodulatory activities on a variety of cell types. These biological activities underlie the mechanism by which this protein is used to treat a variety of diseases, such as hepatitis C infection and multiple sclerosis.

Cytokine 1 Species
Mouse

Applications
This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Introduction
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

Alternative Names
Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1

Gene ID
931

UniProt ID
P11836

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Downloadable Resources

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Datasheet

Datasheet - VS-0624-FY100.pdf

MSDS

MSDS - VS-0624-FY100.pdf

COA

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TAB-016	Anti-Human CD20 Recombinant Antibody (Rituximab)	IF, IP, Neut, FuncS, ELISA, FC, WB	IgG1 - kappa
TAB-1670CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1670CL-F(E))	CDC	Chimeric (mouse/human) Fab
TAB-1671CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1671CL-F(E))	CDC	Chimeric (mouse/human) Fab
TAB-1675CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1675CL-F(E))	ELISA, WB	Chimeric (mouse/human) Fab
TAB-1692CL-F(E)	Anti-Human MS4A1 Recombinant Antibody Fab Fragment (Zytux)	ELISA, WB	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
TAB-017	Anti-Human CD20 Recombinant Antibody (TAB-017)	Neut, ELISA, IF, IP, FuncS, FC, ICC	IgG2a - lambda
TAB-711	Anti-MS4A1 Recombinant Antibody (Technetium (99MTC) Nofetumomab Merpentan)	FC, IP, ELISA, Neut, FuncS, IF, ICC	Fab - G2b - kappa
TAB-001	Anti-Human CD20 Recombinant Antibody (Ibritumomab)	ELISA, IP, FC, FuncS, IF, Neut	IgG1 - kappa
TAB-H27	Anti-Human MS4A1 Recombinant Antibody (Epitumomab)	IP, IF, FuncS, FC, Neut, ELISA, ICC	IgG2a
TAB-H39	Anti-Human MS4A1 Recombinant Antibody (Ibritumomab)	FC, IP, ELISA, Neut, FuncS, IF, ICC	Mouse IgG1 - kappa

CAT	Product Name	Application	Type
TAB-1635CL	Anti-Human MS4A1 Recombinant Antibody (BVX20)	Inhib	Humanized antibody
TAB-1636CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL)	ADCC, CDC	Humanized IgG
TAB-1637CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL)	ADCC, CDC	Humanized IgG
TAB-1638CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL)	ADCC, CDC	Humanized IgG
TAB-1639CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL)	ADCC, CDC, Apop	Humanized IgG

CAT	Product Name	Application	Type
TAB-1645CL	Anti-Human MS4A1 Recombinant Antibody (2.1.2)	Cyt, FuncS	Fully human antibody
TAB-1646CL	Anti-Human MS4A1 Recombinant Antibody (1.1.2)	Cyt, FuncS	Fully human antibody
TAB-1647CL	Anti-Human MS4A1 Recombinant Antibody (1.5.3)	Cyt, FuncS	Fully human antibody
TAB-1648CL	Anti-MS4A1 Recombinant Antibody (MEDI-552)	Inhib
TAB-1654CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1654CL)	FC, Apop	Human IgG1, κ

CAT	Product Name	Application	Type
Gly-059LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-063LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-097LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-115LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Humanized antibody
Gly-138LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-135LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-136LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-137LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-138LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-158LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
Gly-142LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-155LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-171LC	Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application
MHC-LC066	PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC067	APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC068	BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC4347	PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer	FCM

CAT	Product Name	Application	Type
NEUT-1751CQ	Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211)	Neut, FuncS	Mouse IgG1, κ

CAT	Product Name	Application	Type
MOR-2295	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB)	IHC-Fr, IHC-P	Rabbit IgG
MOR-4024	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
FAMAB-0241CQ	Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7)	ELISA, FC, IHC, IP	Mouse IgG2b, κ
HPAB-0247-FY	Human Anti-MS4A1 Recombinant Antibody (HPAB-0247-FY)	Inhib, ELISA	Humanized IgG1
HPAB-0346-WJ	Human Anti-MS4A1 Recombinant Antibody (clone 7F2)	ELISA	Humanized IgG
HPAB-0347-WJ	Human Anti-MS4A1 Recombinant Antibody (clone 8G3)	ELISA	Humanized IgG
HPAB-1583-FY	Mouse Anti-MS4A1 Recombinant Antibody (HPAB-1583-FY)	ELISA	Mouse IgG1

CAT	Product Name	Application	Type
FAMAB-0241CQ-F(E)	Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7); Fab Fragment	ELISA, FC, IHC, IP	Mouse Fab
HPAB-0683-CN-F(E)	Human Anti-MS4A1 Recombinant Antibody (clone Rmut8); Fab Fragment	ELISA, FC	Chimeric (mouse/human) Fab
HPAB-0684-CN-F(E)	Human Anti-MS4A1 Recombinant Antibody (clone Rmut5); Fab Fragment	ELISA, FC	Chimeric (mouse/human) Fab
HPAB-0742-CN-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0742-CN-F(E))	ELISA, FC	Human Fab
HPAB-0743-CN-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0743-CN-F(E))	ELISA, FC	Human Fab

CAT	Product Name	Application	Type
HPAB-1693LY-S(P)	Mouse Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-1693LY-S(P))	Neut, FC, IHC-Fr, IHC-P, IP	Mouse scfv
HPAB-1694LY-S(P)	Human Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-1694LY-S(P))	Inhib	Humanized scfv
HPAB-1583-FY-F(E)	Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1583-FY-F(E))	ELISA, FC	Mouse Fab
HPAB-1584-FY-F(E)	Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1584-FY-F(E))	ELISA, FC	Mouse Fab
HPAB-1585-FY-F(E)	Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1585-FY-F(E))	ELISA, FC	Mouse Fab

CAT	Product Name	Application	Type
HPAB-M0704-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0704-YC)	ELISA, FuncS	Camelid VHH
HPAB-M0705-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0705-YC)	ELISA	Camelid VHH
HPAB-M0706-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC)	ELISA	Camelid VHH
HPAB-M0707-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0707-YC)	ELISA	Camelid VHH
HPAB-M0708-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0708-YC)	ELISA	Camelid VHH

CAT	Product Name	Application	Type
AFC-TAB-772	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-016	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-016)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-028	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-207	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-771	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY188	AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0924-YC138	Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced	FC, CDC, IP	Antibody hexamer
VS-0924-YC139	Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced	FC, Activ, Agonist, IF, WB, Cyt, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY85	Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0125-FY30	Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera	FuncS	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY168	CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A)	FC	Rat IgG2a, kappa

CAT	Product Name	Application	Type
VS-0425-YC513	Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY4510	Anti-MS4A1 Immunohistochemistry Kit	IHC
VS-0525-XY4511	Anti-Mouse MS4A1 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC129	Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv	ELISA, FC	Tandem scFv
VS-0525-YC222	Recombinant Anti-MS4A1 Biparatopic Antibody, Tandem scFv	ELISA, IF, WB	Tandem scFv

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