Anti-CD20 Antibody-Cytokine Fusion Protein, scFv-Fc (Rituximab)-IL2 (CAT#: ACFP-SH133)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD20 scFv-Fc to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD20 as well as the biological activity of IL2. This 2B8-Fc-hIL2 was at least equivalent to the commercial molecule in both binding to Daudi cells and activation of ADCC and may represent a promising plant-derived biopharmaceutical for the treatment of NHLs. This immunocytokine was designed for treating leukemias, lymphomas, rheumatoid arthritis, and other autoimmune diseases.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Target
  • CD20
  • Molecule Class
  • scFv-Fc-IL2
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • Rituximab
  • Related Disease
  • Leukemias, Lymphomas, Rheumatoid arthritis, and other autoimmune diseases
  • Cytokine 1
  • IL2
  • Cytokines 1 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • MS4A1; membrane-spanning 4-domains; subfamily A; member 1; B1; S7; Bp35; CD20; CVID5; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1

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Chimeric Antibody

CAT Product Name Application Type
TAB-016 Anti-Human CD20 Recombinant Antibody (Rituximab) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-207 Anti-Human CD20 Recombinant Antibody ELISA, IP, FC, FuncS, Neut, IF, ICC IgG1 - kappa
TAB-1633CL Anti-Human MS4A1 Recombinant Antibody (ch1F5) FC, Apop, CDC, ADCC, Inhib Chimeric antibody (mouse/human)
TAB-1656CL Anti-Human MS4A1 Recombinant Antibody (ch2B8) FC, CMCD, ADCC, Activ, Inhib, Depletion Chimeric antibody (mouse/human)
TAB-1633CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (ch1F5) FC Chimeric antibody (mouse/human)

Recombinant Antibody

Humanized Antibody

Hyper-galactosylated

High-mannose Glycoform

CAT Product Name Application Type
Gly-155LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-171LC Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) ELISA Chimeric antibody (mouse/human)

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1751CQ Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) Neut, FuncS Mouse IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-772 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-016 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-028 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-207 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-771 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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