This product is a recombinant human anti-Hepatitis C virus monoclonal antibody (e137). e137 and e8 were defined as recognizing two distinct epitopes on HCV/E2 and these epitopes were defined as nonneutralizing. e137 specifically binds to glycoprotein E2 associated with HCV and can be potentially used in the treatment and diagnosis of Hepatitis C virus infection.
Figure 1 Critical residues abrogating mAb binding.
Antibodies are divided into neutralizers and non-neutralizers. Epitope residues are marked in red, while residues that are part of the CD81bs are underlined. The threshold below which a decrease in reactivity defines a residue as part of an epitope was determined for each antibody (e137 < 15%, e20 < 20%, e301 < 20%, e509 < 15%, e10 < 30%, e8 < 20%, H60 < 15%).
A Biologically-validated HCV E1E2 Heterodimer Structural Model
Figure 2 Inhibition of binding of probe FLAG-Fab antigen by previous binding of different concentrations of purified unlabeled Fabs used as competitors.
Mapping B-Cell Epitopes of Hepatitis C Virus E2 Glycoprotein Using Human Monoclonal Antibodies from Phage Display Libraries
Figure 3 Inhibition of binding of human recombinant Fabs by previous binding of a 1:20 dilution of sera obtained from HCV-infected patients and from two HCV-negative controls.
All HCV-positive sera were demonstrated to contain HCV RNA of genotype 1b and to have an ELISA titer against HCV/E2 of>1:500.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-938 | Recombinant Human Anti-HCV E2 Antibody scFv Fragment | ELISA, IHC | scFv |
HPAB-0005-WJ-S(P) | Recombinant Human Anti-HCV E2 Antibody scFv Fragment (HC-84.1) | ELISA, Neut | Human scFv |
HPAB-0050-WJ-S(P) | Mouse Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (HPAB-0050-WJ-S(P)) | ELISA | Mouse scFv |
HPAB-1522WJ-S(P) | Human Anti-HCV E2 protein Recombinant Antibody; scFv Fragment (clone A8) | ELISA, WB | Human scFv |
HPAB-1523WJ-S(P) | Human Anti-HCV E2 protein Recombinant Antibody; scFv Fragment (clone A12) | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-495 | Mouse Anti-HCV E2 Protein Recombinant Antibody (PABL-495) | ELISA, Neut | Mouse IgG |
PABL-496 | Recombinant Mouse Anti-HCV E2 Antibody (AP33) | FC, Neut, FuncS | IgG |
PABL-497 | Recombinant Human Anti-HCV E2 Antibody (AR3C) | Neut | IgG |
PABL-498 | Recombinant Human Anti-HCV E2 Antibody (C2) | Neut | IgG |
PABL-499 | Recombinant Human Anti-HCV E2 Antibody (HC33.8) | Neut | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-492 | Mouse Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (PFBL-492) | ELISA, Neut | Mouse Fab |
PFBL-493 | Recombinant Mouse Anti-HCV E2 Antibody Fab Fragment (AP33) | ELISA | Fab |
PFBL-494 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (AR3C) | Neut | Fab |
PFBL-495 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (C2) | Neut | Fab |
PFBL-496 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (HC33.8) | Neut | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-437LC | Anti-HCV E2 Recombinant Antibody (503) | ELISA | Human antibody |
MRO-438LC | Anti-HCV E2 Recombinant Antibody (108) | ELISA | Human antibody |
MRO-437LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (503) | ELISA | Human antibody |
MRO-438LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (108) | ELISA | Human antibody |
MRO-467LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (7F2) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-476LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-476LC) | ELISA, Inhib | Chimeric (mouse/human) IgG |
MRO-476LC-S(P) | Mouse Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-476LC-S(P)) | ELISA | Mouse scFv |
MRO-476LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-476LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-477LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-477LC) | ELISA | Humanized IgG1, κ |
MRO-478LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-478LC) | ELISA | Humanized IgG1, κ |
MRO-477LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-477LC-F(E)) | ELISA | Humanized Fab |
MRO-478LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-478LC-F(E)) | ELISA | Humanized Fab |
MRO-479LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-479LC-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1191LC | Anti-HCV E2 Recombinant Antibody (A10F2) | ELISA, Inhib | Mouse Antibody |
MRO-1192LC | Anti-HCV E2 Recombinant Antibody (H6D3) | ELISA, Inhib, WB | Mouse Antibody |
MRO-1193LC | Anti-HCV E2 Recombinant Antibody (E3D8) | ELISA, Inhib, WB | Mouse Antibody |
MRO-1194LC | Anti-HCV E2 Recombinant Antibody (A7A6H9) | ELISA, Inhib | Mouse Antibody |
MRO-1195LC | Anti-HCV E2 Recombinant Antibody (G9E1) | ELISA, Inhib | Mouse Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC428 | PE-A*24:02/HCV E2 (EYVLLLFLL) MHC Tetramer | FCM | |
MHC-LC429 | APC-A*24:02/HCV E2 (EYVLLLFLL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0065LC | Recombinant Mouse Anti-HCV E2 protein Antibody (JS-81) | ELISA | IgG1 |
EPAF-1294LC | Recombinant Human Anti-HCV E2 protein Antibody (4c2) | ELISA |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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