Products

Pascolizumab (TAB-221)

Recombinant monoclonal antibody to IL4. Pascolizumab is a humanized monoclonal antibody for the treatment of asthma.      

  • Published Data
  • Datasheet

Figure 1 Effect of pascolizumab binding of IL‐4 inhibits IL‐4 interaction with the alpha chain of the IL‐4 receptor.

IL=interleukin; anti‐IL‐4=antibody against IL‐4; γ C=gamma signalling chain of the IL‐4 receptor; IL‐4Rα=IL‐4 receptor alpha; IL‐13Rα=IL‐13 receptor alpha.

Hart, T. K. , Blackburn, M. N. , Brigham-Burke, M. , Dede, K. , Al-Mahdi, N. , & Zia-Amirhosseini, P. , et al. (2010). Preclinical efficacy and safety of pascolizumab (sb 240683): a humanized anti‐interleukin‐4 antibody with therapeutic potential in asthma. Clin.exp.immunol, 130(1), 93-100.

Figure 2 Effect of MoAb 3B9 and pascolizumab on IL‐4‐dependent IgE synthesis from human PBMCs.

(a) and surface expression of CD23 on purified human tonsillar B cells (b). Results are expressed as percentage of the control response obtained with IL‐4‐stimulated cells. •, MoAb 3B9; , pascolizumab.

Hart, T. K. , Blackburn, M. N. , Brigham-Burke, M. , Dede, K. , Al-Mahdi, N. , & Zia-Amirhosseini, P. , et al. (2010). Preclinical efficacy and safety of pascolizumab (sb 240683): a humanized anti‐interleukin‐4 antibody with therapeutic potential in asthma. Clin.exp.immunol, 130(1), 93-100.


Specifications
Immunogen
The details of the immunogen for this antibody are not available.
Host
Mouse
Derivation
Humanized (from mouse)
Type
IgG1 - kappa
Specificity
Tested positive against native human antigen.
Species Reactivity
Human
Applications
WB, ELISA, FC, IP, FuncS, IF, Neut
CAS NO.
331243-22-2
Generic Name
Pascolizumab
UNII
N1IOA09R6A
Related Disease
Allergy
Applications
Application Notes
The IL4 antibody has been reported in applications of Inhib, Neut.
Target
Alternative Names
Pascolizumab; 331243-22-2; SB-240683; IL4; interleukin 4; interleukin-4; B cell growth factor 1; B_cell stimulatory factor 1
Entrez Gene ID
3565
UniProt ID
P05112

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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