Recombinant Anti-human KDR Intrabody [(D-Arg)9] (CAT#: IAB-B066(A))
Recombinant anti-KDR intrabody linked to (D-Arg)9 works within cells to block the transport of KDR, expressed in E. coli cells. It can inhibit VEGF induced signalling and affect the maturation of the receptor.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

(Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg

(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg

(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg

(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg

(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR
Specifications
- Immunogen
- human kinase insert domain receptor
- Host Species
- mouse
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Flow Cytometry; Immunofluorescence; Functional studies
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- Store at -20°C. Open under aseptic conditions.
Target
- Alternative Names
- KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kina
- Gene ID
- 3791
- UniProt ID
- A0A024RD88
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "KDR"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B066(G) | Recombinant Anti-human KDR Intrabody [+36 GFP] | CO-IP, FuncS | scFv-(+36GFP) |
IAB-B066(T) | Recombinant Anti-human KDR Intrabody [Tat] | IF, ELISA, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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