Afuco™ Anti-ACVRL1 ADCC Recombinant Antibody (Ascrinvacumab), ADCC Enhanced (CAT#: AFC-TAB-003ML)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to ACVRL1. Ascrinvacumab is a human monoclonal antibody that can be potentially used in the treatment of Mesothelioma, pleural malignant, Hepatocellular carcinoma (HCC).
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong granular cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/ihc_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows strong granular cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/ihc_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_B_7_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_7_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_7_3.jpg
Figure 4 Gallbladder
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_5_4.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_5_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_8_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_8_5.jpg
Figure 6 Testis
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_6_6.jpg
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_6_6.jpg
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_9_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139567-ACVRL1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139567-ACVRL1
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Specificity
- Human ACVRL1
- Species Reactivity
- Human
- Clone
- Ascrinvacumab
- Applications
- ELISA, IHC, FC, IP, IF, Inhib
- Conjugate
- Unconjugated
- Generic Name
- Ascrinvacumab
- Related Disease
- Mesothelioma, pleural malignant, Hepatocellular carcinoma (HCC)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Activin A receptor type II-like 1; activin receptorlike kinase 1; ALK1; ALK-1; serine/threonine-protein kinase receptor R3; SKR3; transforming growth factor-beta superfamily receptor type I; TGF-B superfamily receptor type I; TSR-I; HHT2; ORW2
- Gene ID
- 94
- UniProt ID
- P37023
Related Resources
Please refer to Ascrinvacumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ascrinvacumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ascrinvacumab"
Anti-Human ACVRL1 Recombinant Antibody (Ascrinvacumab)Recombinant monoclonal antibody to ACVRL1. Ascrinvacumab is a human monoclonal antibody that can be potentially used in the treatment of Mesothelioma, pleural malignant, Hepatocellular carcinoma (HCC).
See other products for "ACVRL1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3390z | Mouse Anti-ACVRL1 Recombinant Antibody (clone 39H9) | IHC, WB, FC | Mouse IgG2a |
| HPAB-0136-CN | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05444) | ELISA, IHC | Human IgG1 |
| HPAB-0137-CN | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05377) | ELISA, IHC | Human IgG1 |
| HPAB-J0024-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0024-YC) | ELISA, FC, WB | Human IgG1 |
| HPAB-J0025-YC | Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0025-YC) | ELISA, FC, WB | Human IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0065 | Hi-Affi™ Rabbit Anti-ACVRL1 Recombinant Antibody (clone DS65AB) | ELISA | Rabbit IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-003ML | Anti-Human ACVRL1 Recombinant Antibody (Ascrinvacumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG2, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0137-CN-F(E) | Human Anti-ACVRL1 Recombinant Antibody (clone MOR05377); Fab Fragment | ELISA, IHC | Human Fab |
| HPAB-J0024-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0024-YC-F(E)) | ELISA, FC, WB | Human Fab |
| HPAB-J0025-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0025-YC-F(E)) | ELISA, FC, WB | Human Fab |
| HPAB-J0026-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0026-YC-F(E)) | ELISA, FC, WB, Inhib, FuncS | Human Fab |
| HPAB-J0027-YC-F(E) | Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0027-YC-F(E)) | ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0024-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0024-YC-S(P)) | ELISA, FC, WB | Human scFv |
| HPAB-J0025-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0025-YC-S(P)) | ELISA, FC, WB | Human scFv |
| HPAB-J0026-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0026-YC-S(P)) | ELISA, FC, WB, Inhib, FuncS | Human scFv |
| HPAB-J0027-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0027-YC-S(P)) | ELISA | Human scFv |
| HPAB-J0028-YC-S(P) | Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0028-YC-S(P)) | ELISA, FC, WB | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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