Rabbit Anti-MAPK8 Recombinant Antibody (VS3-FY2764) (CAT#: VS3-FY2764)
The anti-MAPK8 antibody is a rabbit recombinant monoclonal antibody that is specifically created to bind human JNK protein. It cross-reacts with mouse, rat and hamster. This monoclonal antibody is potential for conducting research on disease research of Hepatitis C and Hepatitis. This monoclonal antibody can be used in Western Blot, Immunoprecipitation assays.
| Sub Cat | Species Reactivity | Application | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2780 | Human, Mouse, Rat, Hamster | WB, IP |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 |
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| VS3-FY2765 | Mouse, Rat | WB, ICC, IP |
Immunoprecipitation: 1/20 Western Blot: 1/500-1/1000 Immunocytochemistry: 1/50-1/200 |
More Infomation
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 IHC staining of human breast
(Immunohistochemical staining of human breast shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/ihc_selected.jpg
(Immunohistochemical staining of human breast shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/ihc_selected.jpg
Figure 2 IHC staining of human thyroid gland
(Immunohistochemical staining of human thyroid gland shows moderate cytoplamsic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69396/ihc_selected.jpg
(Immunohistochemical staining of human thyroid gland shows moderate cytoplamsic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69396/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12466_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12466_B_8_5.jpg
Figure 4 Colon
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_7_3.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_7_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_7_5.jpg
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_7_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_4_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_4_6.jpg
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4463/12962_A_8_8.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107643-MAPK8
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107643-MAPK8
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Mitogen-activated protein kinase 8 of human, mouse, rat and Hamster origins
- Conjugate
- Unconjugated, FITC
- Related Disease
- Hepatitis C and Hepatitis
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Mitogen-Activated Protein Kinase 8; Stress-Activated Protein Kinase 1c; C-Jun N-Terminal Kinase 1; JUN N-Terminal Kinase; MAP Kinase 8; EC 2.7.11.24; JNK-46; SAPK1c; PRKM8; SAPK1; JNK1
- Gene ID
- 5599
- UniProt ID
- P45983
- Sequence Similarities
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Cellular Localization
- Cytoplasm
Nucleus
Synapse
- Post Translation Modifications
- Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme.
Phosphorylated by TAOK2.
May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1.
Phosphorylated form is more concentrated at synapses than none-phosphorylated (By similarity).
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_024303847.1; XP_024303848.1; XP_047281436.1; XP_047281437.1; XP_047281438.1
- Function
- Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death.
Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
FcεR1 Signaling Pathway
TCR Signaling Pathway
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "MAPK8"
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IgG Antibody Products
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1000CT | Recombinant Mouse anti-Human MAPK8 Monoclonal antibody (4E3) | ELISA, WB | |
| ZG-0523J | Mouse Anti-MAPK8 Recombinant Antibody (ZG-0523J) | WB, ICC | Mouse IgG |
| VS3-FY890 | Recombinant Rabbit Anti-MAPK8 (phospho Thr183/Tyr185) Antibody (clone R02-0F1) | WB, IP | Rabbit IgG |
| VS3-FY891 | Recombinant Rabbit Anti-MAPK8 Antibody (clone R08-7H1) | WB | Rabbit IgG |
| VS7-0425-WR358 | Mouse Anti-MAPK8 Recombinant Antibody (clone 1E5) | WB, FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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