Mouse Anti-MBP Recombinant Antibody (clone PT0183)
CAT#: VS3-CJ302
This product is a mouse antibody that recognizes MBP.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64368/1577_H5_1_selected.jpg
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Specifications
- Immunogen
- Synthesized peptide derived from human Myelin Basic Protein (MBP)
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human MBP
- Species Reactivity
- Human
- Clone
- PT0183
- Applications
- IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- Myelin basic protein; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein
- Gene ID
- 4155
- UniProt ID
- P02686
- Sequence Similarities
- Belongs to the myelin basic protein family.
- Cellular Localization
- Cell membrane, Membrane, Nucleus
- Post Translation Modifications
- Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).
Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells.
Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.
- Protein Refseq
- NP_001020252.1; NP_001020261.1; NP_001020263.1
- Function
- The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
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Related Diseases
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Recommended Dilution Buffer
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0216CQ-S(P) | Mouse Anti-MBP Recombinant Antibody (clone 845D3); scFv Fragment | ELISA, WB | Mouse scFv |
| FAMAB-0217-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (E2) | WB, ELISA, IP | Human scFv |
| FAMAB-0218-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (F11) | WB, ELISA, IP | Human scFv |
| FAMAB-0219-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (E6) | WB, ELISA, IP | Human scFv |
| FAMAB-0220-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (D1) | WB, ELISA, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0107-CN | Mouse Anti-MBP Recombinant Antibody (clone IN-1) | WB, IF, IP, Block | Mouse IgM, Κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0107-CN-F(E) | Mouse Anti-MBP Recombinant Antibody (clone IN-1); Fab Fragment | WB, IF, IP, Block | Mouse Fab |
| FAMAB-0217-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (E2) | WB, ELISA, IP | Human Fab |
| FAMAB-0218-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (F11) | WB, ELISA, IP | Human Fab |
| FAMAB-0219-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (E6) | WB, ELISA, IP | Human Fab |
| FAMAB-0220-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (D1) | WB, ELISA, IP | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY31 | Human Anti-MBP (clone W25MBP10) scFv-Fc Chimera | ADCC, CDC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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