Mouse Anti-MBP Monoclonal Antibody (VS7-0425-WR975)
CAT#: VS7-0425-WR975
This product is a mouse IgG antibody that binds to human MBP. The antibody can be used for WB and ELISA assays.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/64368/1577_H5_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
nuclear
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_9_5.jpg
Normal Tissue
Figure 3 Caudate
Glial cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2300/6024_B_8_7.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (HL-60, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000197971-MBP
❮
❯
Specifications
- Immunogen
- MBP-tagged recombinant fusion protein
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human MBP
- Species Reactivity
- Human
- Molecule Class
- Myelin Basic Protein
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
- Related Disease
- Autoimmune encephalomyelitis
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis, Ascitic fluid
- Format
- Liquid
- Concentration
- 1 mg/ml
- Preservative
- 0.03% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Aliquot and store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- Myelin Basic Protein; Myelin Membrane Encephalitogenic Protein; Myelin A1 Protein; Golli-MBP
- Gene ID
- 4155
- UniProt ID
- P02686
- Long Name
- Myelin Basic Protein
- Cellular Localization
- Cell membrane; Membrane; Nucleus
- Post Translation Modifications
- Acetylation; Citrullination; Methylation; Phosphoprotein
- Protein Refseq
- NP_001020252.1
- Function
- The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
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Related Diseases
Asthma
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| FAMAB-0217-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (E2) | WB, ELISA, IP | Human scFv |
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| FAMAB-0220-CN-S(P) | Recombinant Human Anti-MBP Antibody scFv Fragment (D1) | WB, ELISA, IP | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| FAMAB-0217-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (E2) | WB, ELISA, IP | Human Fab |
| FAMAB-0218-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (F11) | WB, ELISA, IP | Human Fab |
| FAMAB-0219-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (E6) | WB, ELISA, IP | Human Fab |
| FAMAB-0220-CN-F(E) | Recombinant Human Anti-MBP Antibody Fab Fragment (D1) | WB, ELISA, IP | Human Fab |
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| VS-1024-XY316 | Mouse Anti-NHP MBP Recombinant Antibody (clone MBP101) | WB, IF, ELISA | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY31 | Human Anti-MBP (clone W25MBP10) scFv-Fc Chimera | ADCC, CDC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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