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CXCR5 & CD3

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Anti-CXCR5 & CD3 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
CXCR5 encodes a receptor for the chemokines CXCL13, which is involved in the migration and organization of B cells and T follicular helper cells within lymphoid tissues. CXCR5 is crucial for the formation of B cell follicles in secondary lymphoid organs, such as the spleen and lymph nodes, and plays a vital role in immune surveillance. Mutations in CXCR5 can lead to defects in immune responses, particularly in the formation of germinal centers, which are important for antibody production and the defense against infections.
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