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EGFR & CD28

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The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
EGFR & CD28
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
EGFR & CD28
  • Cetuximab (Gly-015CL)
    • CAS number: 205923-56-4
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  • Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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  • Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: MTX
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  • Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
    • Target: EGFR
    • Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
    • Drug: doxorubicin
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  • Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
    • Target: EGFR variant III
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
    • Target: EGFRvIII
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
    • Target: EGFR
    • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: doxorubicin
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  • Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
    • Target: epidermal growth factor receptor (EGFR)
    • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MODO (monomethyldolastatin)
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  • Anti-EGFR-mc-MMAF ADC (ADC-039CL)
    • Target: EGFR
    • Linker: Mc (maleimidocaproyl)
    • Drug: MMAF (Monomethyl auristatin F)
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  • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
    • Target: EGFR
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
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  • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
    • Target: EGFR
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
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