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    EGFR & CD28

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    Anti-EGFR & CD28 Products

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
    EGFR & CD28
    CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Th2 Differentiation Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.
    EGFR & CD28
    Related Diseases
    Bladder Cancer Bladder Cancer
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Pancreatic Cancer Pancreatic Cancer
    Rheumatoid Arthritis Rheumatoid Arthritis
    Systemic Lupus Erythematosus Systemic Lupus Erythematosus
    Hepatocellular Carcinoma Hepatocellular Carcinoma
    Allograft Rejection Allograft Rejection
    Autoimmune Thyroid Disease Autoimmune Thyroid Disease
    Graft-versus-Host Disease Graft-versus-Host Disease
    Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young
    Cushing Syndrome Cushing Syndrome
    Related Signaling Pathways
    JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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