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    EGFR & MET

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    Anti-EGFR & MET Products

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    • Anti-Human Met(Onartuzumab) (TAB-190-F(E))
      • Derivation: Humanized (from mouse)
      • Species Reactivity: Human
      • Type: Fab / Fc - G1 - kappa
      • Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
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    • Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
      • Target: EGFR
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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    • Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
      • Target: EGFR
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: MTX
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    • Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
      • Target: EGFR variant III
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
      • Target: EGFR
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
      • Target: EGFR
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
      • Target: EGFRvIII
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
      • Target: EGFR
      • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: doxorubicin
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    • Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
      • Target: EGFR
      • Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
      • Drug: doxorubicin
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    • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
      • Target: EGFR
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-EGFR-mc-MMAF ADC (ADC-039CL)
      • Target: EGFR
      • Linker: Mc (maleimidocaproyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
      • Target: epidermal growth factor receptor (EGFR)
      • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MODO (monomethyldolastatin)
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
    EGFR & MET
    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
    EGFR & MET
    Related Diseases
    Bladder Cancer Bladder Cancer
    EGFR Tyrosine Kinase Inhibitor Resistance EGFR Tyrosine Kinase Inhibitor Resistance
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Pancreatic Cancer Pancreatic Cancer
    Hepatocellular Carcinoma Hepatocellular Carcinoma
    Cushing Syndrome Cushing Syndrome
    Related Signaling Pathways
    JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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