Anti-EpCAM (clone MOC31)-hydrazone-Doxorubicin ADC
CAT#: ADC-149LZY
This ADC product is composed of an anti-EpCAM antibody (clone MOC31) conjugated via hydrazone
linker to Doxorubicin (MOC31-hydrazone-Doxorubicin). It has demonstrated a response in colon cancer treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase II and causing DNA damage.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67463/1592_H11_2_selected.jpg
Normal Tissue
Figure 2 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_B_2_5.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119888-EPCAM
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Specifications
- Antibody Overview
- Murine Anti-EpCAM Antibody,MOC31
- Clone
- MOC31
- Linker
- acid-cleavable hydrazone
linker
- Linker Class/Description
- Class: Chemically cleavable Linker-Acid-labile linker
Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.
- Drug
- Doxorubicin
- Drug Class/Description
- Class: Doxorubicin
Description: Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.
Target
- Introduction
- This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein);
- Gene ID
- 4072
- UniProt ID
- P16422
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Datasheet
MSDS
COA
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See other products for "Clone MOC31"
- CAT
- Product Name
See other products for "EPCAM"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1093z | Mouse Anti-EPCAM Recombinant Antibody (clone 41D5) | WB, FC, IHC, IP, FuncS | Mouse IgG1, κ |
| MOB-074LC | Human Anti-EPCAM Recombinant Antibody (clone ING-1) | ELISA, FuncS | Humanized IgG1, κ |
| FAMAB-0095YC | Mouse Anti-EPCAM Recombinant Antibody (clone MOC31) | ELISA | Mouse IgG1, κ |
| HPAB-2219LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2219LY) | ELISA | Human IgG |
| HPAB-2220LY | Human Anti-EPCAM Recombinant Antibody (HPAB-2220LY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-213 | Humanized Anti-EPCAM Recombinant Antibody (clone Tucotuzumab) | WB, Neut, ELISA, IF, IP, FuncS, FC | Humanized (from mouse) IgG1 |
| TAB-362MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (3622W94) | Confocal, ELISA | Humanized antibody |
| TAB-374MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (h12H8B) | FC, ELISA | Humanized antibody |
| TAB-375MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (h12H8C) | FC, ELISA | Humanized antibody |
| TAB-376MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (h2D11B) | FC, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L013E | anti-EPCAM immunotoxin MOC31 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L013D | anti-EPCAM immunotoxin MOC31 (IgG)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L013G | anti-EPCAM immunotoxin MOC31 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
| AGTO-L013R | anti-EPCAM immunotoxin MOC31 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L013O | anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0531CL-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (HE2) | ELISA, Inhib | |
| TAB-363MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-363MZ) | ELISA, FuncS | Mouse IgG1, κ |
| TAB-364MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-364MZ) | FC | Mouse IgG1 |
| TAB-365MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-365MZ) | FC | Mouse IgG1 |
| TAB-366MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-366MZ) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-356MZ | Anti-Human EPCAM Recombinant Antibody (3-171) | Cyt, ELISA, FC, WB | Human antibody |
| TAB-357MZ | Anti-Human EPCAM Recombinant Antibody (7-F17) | ELISA | Human antibody |
| TAB-358MZ | Anti-Human EPCAM Recombinant Antibody (12-C15) | ELISA | Human antibody |
| TAB-359MZ | Anti-Human EPCAM Recombinant Antibody (16-G5) | ELISA | Human antibody |
| TAB-360MZ | Anti-Human EPCAM Recombinant Antibody (17-C20) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1163 | Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) | IHC-P, WB, ICC, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0538-CN | Mouse Anti-EPCAM Recombinant Antibody (clone 3-E1-E2) | WB, IF, IHC, FC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-106 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-106) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-213 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-213) | Neut, ELISA, IF, IP, FuncS | ADCC enhanced antibody |
| AFC-TAB-701 | Afuco™ Anti-EpCAM ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-701) | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2216LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) | ELISA | Human Fab |
| HPAB-2217LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2217LY-F(E)) | ELISA | Human Fab |
| HPAB-2218LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2218LY-F(E)) | ELISA | Human Fab |
| HPAB-2219LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2219LY-F(E)) | ELISA | Human Fab |
| HPAB-2220LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2220LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2218LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2218LY-S(P)) | ELISA | Human scFv |
| HPAB-2219LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2219LY-S(P)) | ELISA | Human scFv |
| HPAB-2220LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2220LY-S(P)) | ELISA | Human scFv |
| HPAB-2221LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2221LY-S(P)) | ELISA | Human scFv |
| HPAB-2222LY-S(P) | Human Anti-EPCAM Recombinant Antibody; scFv Fragment (HPAB-2222LY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0031 | APC-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM | |
| MHC-CN0032 | PE-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1517 | AbPlus™ Anti-EPCAM Magnetic Beads (VS-0724-YC1517) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC37 | Mouse Anti-EPCAM Recombinant Antibody (VS-0924-YC37) - Cancer Stem Cell Marker | IHC, WB | Mouse IgG1 |
| VS-0924-YC38 | Rabbit Anti-EPCAM Antibody (VS-0924-YC38) - Cancer Stem Cell Marker | IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY18 | Human Anti-EpCAM (clone 3-171) scFv-Fc Chimera | Cyt, ELISA, FC, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY107 | CytoStream™ Mouse Anti-EPCAM Recombinant Antibody (VS-0225-XY107) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY773 | Anti-EPCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY2307 | Anti-Human EPCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY2308 | Anti-Mouse EPCAM Immunohistochemistry Kit | IHC | |
| VS-0525-XY2309 | Anti-Canine EPCAM Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC210 | Recombinant Anti-EPCAM Vesicular Antibody, EV Displayed (VS-0425-YC210) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC214 | Recombinant Anti-EpCAM (Exon 2 x Exon 5) Biparatopic Antibody, Tandem scFv (Edrecolomab x Adecatumumab) | ELISA, FC | Tandem scFv |
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