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Anti-EpCAM (clone MOC31)-hydrazone-Doxorubicin ADC (CAT#: ADC-149LZY)

This ADC product is composed of an anti-EpCAM antibody (clone MOC31) conjugated via hydrazone
linker to Doxorubicin (MOC31-hydrazone-Doxorubicin). It has demonstrated a response in colon cancer treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase II and causing DNA damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67463/1592_H11_2_selected.jpg
Normal Tissue
Figure 2 Thyroid gland
Figure 2 Thyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_B_2_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_9_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55098/120585_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119888-EPCAM
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119888-EPCAM

Specifications

  • Antibody Overview
  • Murine Anti-EpCAM Antibody,MOC31
  • Clone
  • MOC31
  • Linker
  • acid-cleavable hydrazone
    linker
  • Linker Class/Description
  • Class: Chemically cleavable Linker-Acid-labile linker
    Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.
  • Drug
  • Doxorubicin
  • Drug Class/Description
  • Class: Doxorubicin
    Description: Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

Target

  • Introduction
  • This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
  • Alternative Names
  • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein);

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Humanized Antibody

CAT Product Name Application Type
TAB-213 Humanized Anti-EPCAM Recombinant Antibody (clone Tucotuzumab) WB, Neut, ELISA, IF, IP, FuncS, FC Humanized (from mouse) IgG1
TAB-112-F(E) Anti-Human EpCAM Recombinant Antibody Fab Fragment, 17-1A (Citatuzumab Bogatox) Neut, ELISA, IF, IP, FuncS, FC, ICC Fab - G1 - kappa
TAB-374MZ Anti-Human EPCAM Recombinant Antibody (h12H8B) FC, ELISA Humanized antibody
TAB-375MZ Anti-Human EPCAM Recombinant Antibody (h12H8C) FuncS, Inhib Humanized antibody
TAB-376MZ Anti-Human EPCAM Recombinant Antibody (h2D11B) Cyt, Inhib Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L013E anti-EPCAM immunotoxin MOC31 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L013D anti-EPCAM immunotoxin MOC31 (IgG)-DT Cytotoxicity assay, Functional assay
AGTO-L013G anti-EPCAM immunotoxin MOC31 (IgG)-Gel Cytotoxicity assay, Functional assay
AGTO-L013R anti-EPCAM immunotoxin MOC31 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L013O anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-356MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (3-171) FC, ELISA Human antibody
TAB-357MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (7-F17) FC, ELISA Human antibody
TAB-358MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (12-C15) FC, ELISA Human antibody
TAB-359MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (16-G5) FC, ELISA Human antibody
TAB-360MZ-S(P) Anti-Human EPCAM Recombinant Antibody scFv Fragment (17-C20) FC, ELISA Human antibody

Mouse Antibody

CAT Product Name Application Type
TAB-363MZ-S(P) Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-363MZ-S(P)) Confocal, ELISA Mouse scFv
TAB-364MZ-S(P) Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-364MZ-S(P)) NIR (Near-infrared) fluorescence imaging, ELISA Mouse scFv
TAB-365MZ-S(P) Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-365MZ-S(P)) NIR (Near-infrared) fluorescence imaging, ELISA Mouse scFv
TAB-366MZ-S(P) Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-366MZ-S(P)) ELISA, WB, IHC Mouse scFv
TAB-367MZ-S(P) Mouse Anti-EPCAM Recombinant Antibody; scFv Fragment (TAB-367MZ-S(P)) ELISA, WB, IHC Mouse scFv

Recombinant Antibody

CAT Product Name Application Type
MOB-0093MZ Recombinant Mouse Anti-Ep-CAM Antibody (clone IEA126) IHC, WB, IF Mouse antibody
MOB-074LC Human Anti-EPCAM Recombinant Antibody (clone ING-1) ELISA, FuncS Humanized IgG1, κ
HPAB-2216LY Human Anti-EPCAM Recombinant Antibody (HPAB-2216LY) ELISA Human IgG
HPAB-2217LY Human Anti-EPCAM Recombinant Antibody (HPAB-2217LY) ELISA Human IgG
HPAB-2218LY Human Anti-EPCAM Recombinant Antibody (HPAB-2218LY) ELISA Human IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1163 Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) IHC-P, WB, ICC, ICC, IF Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0163CQ-F(E) Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54); Fab Fragment ELISA, FC, FuncS Human Fab
HPAB-2216LY-F(E) Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) ELISA Human Fab
HPAB-2217LY-F(E) Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2217LY-F(E)) ELISA Human Fab
HPAB-2218LY-F(E) Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2218LY-F(E)) ELISA Human Fab
HPAB-2219LY-F(E) Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2219LY-F(E)) ELISA Human Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-106 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody
AFC-TAB-213 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS ADCC enhanced antibody
AFC-TAB-701 Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-CN0031 APC-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer FCM
MHC-CN0032 PE-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer FCM

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0639-YJ-S(P) Mouse Anti-EPCAM Recombinant Antibody (clone ch FU-MK-1); scFv Fragment ELISA, FC, WB Mouse scFv
HPAB-S0025-YC-S(P) Mouse Anti-EPCAM Recombinant Antibody (clone M79); scFv Fragment ELISA, FC Mouse scFv
HPAB-S0026-YC-S(P) Human Anti-EPCAM Recombinant Antibody (clone H79); scFv Fragment ELISA, FC, Cyt Human scFv
HPAB-2050-FY-S(P) Human Anti-EpCAM Recombinant Antibody (clone K53); scFv Fragment FC Human scFv
HPAB-2051-FY-S(P) Human Anti-EpCAM Recombinant Antibody (clone 02-237); scFv Fragment FC Human scFv

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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