Anti-EpCAM (clone MOC31)-hydrazone-Doxorubicin ADC (CAT#: ADC-149LZY)

• Antibody Overview
• Murine Anti-EpCAM Antibody,MOC31

• Clone
• MOC31

• Linker
• acid-cleavable hydrazone
  linker

• Linker Class/Description
• Class: Chemically cleavable Linker-Acid-labile linker
  Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.

• Drug
• Doxorubicin

• Drug Class/Description
• Class: Doxorubicin
  Description: Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

• Introduction
• This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]

• Alternative Names
• EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein);

• Gene ID
• 4072

• UniProt ID
• P16422

• AGTO-L013E
• anti-EPCAM immunotoxin MOC31 (IgG)-PE

• AGTO-L013D
• anti-EPCAM immunotoxin MOC31 (IgG)-DT

• AGTO-L013G
• anti-EPCAM immunotoxin MOC31 (IgG)-Gel

• AGTO-L013R
• anti-EPCAM immunotoxin MOC31 (IgG)-RTA

• AGTO-L013O
• anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin

• FAMAB-0095YC
• Mouse Anti-EPCAM Recombinant Antibody (clone MOC31)

• FAMAB-0095-YC-S(P)
• Mouse Anti-EPCAM Recombinant Antibody (clone MOC31); scFv Fragment

• FAMAB-0095-YC-F(E)
• Mouse Anti-EPCAM Recombinant Antibody (clone MOC31); Fab Fragment

• FAMAB-0095YC-mRNA
• Mouse Anti-EpCAM Antibody (clone MOC31), mRNA

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