Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ipilimumab), ADCC Enhanced (CAT#: AFC-TAB-067)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CTLA4. Ipilimumab (known as MDX-010 and MDX-101), marketed as Yervoy, is a drug used for the treatment of melanoma, a type of skin cancer. It is a U.S. Food and Drug Administration (FDA) approved human monoclonal antibody, and works by activating the immune system by targeting CTLA-4.
Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, there is also an inhibitory mechanism that interrupts this destruction. Ipilimumab turns off this inhibitory mechanism and allows CTLs to continue to destroy cancer cells.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163599-CTLA4
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Ipilimumab
- Applications
- FuncS, IF, Neut, ELISA, FC
- Conjugate
- Unconjugated
- Trade name
- Yervoy
- Generic Name
- Ipilimumab
- Related Disease
- Melanoma, metastatic
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Ipilimumab; yervoy; 477202-00-9; MDX-010; MDX-101; Yervoy; MDX-010; MDX-101; CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3, CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3;
- Gene ID
- 1493
- UniProt ID
- P16410
Related Resources
Rheumatoid Arthritis
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ipilimumab"
Anti-Human CTLA4 Recombinant Antibody (Ipilimumab)Recombinant monoclonal antibody to CTLA4. Ipilimumab (known as MDX-010 and MDX-101), marketed as Yervoy, is a drug used for the treatment of melanoma, a type of skin cancer. It is a U.S. Food and Drug Administration (FDA) approved human monoclonal antibody, and works by activating the immune system by targeting CTLA-4.
Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, there is also an inhibitory mechanism that interrupts this destruction. Ipilimumab turns off this inhibitory mechanism and allows CTLs to continue to destroy cancer cells.
See other products for "CTLA4"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-067 | Anti-Human CTLA4 Recombinant Antibody (Ipilimumab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-206 | Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgG2 |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G015E | Anti-CTLA4 immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G015S | Anti-CTLA4 immunotoxin (scFv)-Sap | Cytotoxicity assay, Function study | |
| AGTO-G015M | Anti-CTLA4 immunotoxin (scFv)-Mel | Cytotoxicity assay, Function study |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195CL | Mouse Anti-CTLA4 Recombinant Antibody (TAB-195CL) | ELISA | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-083MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2122.H) | ELISA, FC | Humanized antibody |
| TAB-084MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2422.H) | ELISA, FC | Humanized antibody |
| TAB-088MZ | Human Anti-CTLA4 Recombinant Antibody (TAB-088MZ) | ELISA | Human IgG |
| TAB-091MZ | Human Anti-CTLA4 Recombinant Antibody (TAB-091MZ) | ELISA | Human IgG1 |
| TAB-092MZ | Human Anti-CTLA4 Recombinant Antibody (TAB-092MZ) | ELISA | Human IgG1 |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-085MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-086MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2422.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-085MZ-S(P) | Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-085MZ-F(E) | Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-086MZ-F(E) | Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2422.C) | ELISA, FC | Chimeric antibody (mouse/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-087MZ | Mouse Anti-CTLA4 Recombinant Antibody (TAB-087MZ) | ELISA | Mouse IgG |
| TAB-089MZ | Mouse Anti-CTLA4 Recombinant Antibody (TAB-089MZ) | ELISA | Mouse IgG1 |
| TAB-090MZ | Mouse Anti-CTLA4 Recombinant Antibody (TAB-090MZ) | ELISA | Mouse IgG1 |
| TAB-093MZ | Anti-Human CTLA4 Recombinant Antibody (Mu-26B) | ELISA | |
| TAB-087MZ-S(P) | Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-087MZ-S(P)) | ELISA | Mouse scFv |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-567CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone 14D3) | FC, FuncS, Neut, IP, WB | Mouse IgG2a, κ |
| NEUT-569CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone AS32) | WB, Neut | Mouse IgG1 |
| NEUT-570CQ | Human Anti-CTLA4 Recombinant Antibody (clone YC030) | Neut | Human IgG1, κ |
| NEUT-572CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone UC10-4B9) | FC, Block, ELISA, IP | Hamster IgG |
| NEUT-573CQ | Rat Anti-Ctla4 Recombinant Antibody (clone 63828) | WB, FC, Neut | Rat IgG2a |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-568CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone L3D10) | FC, Block | Mouse IgG1, κ |
| NEUT-571CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone BN13) | Block, FC | Mouse IgG2a |
| NEUT-577CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone MAB0835) | Block, FC | Hamster IgG |
| NEUT-578CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone RYNmCTLA-4) | Block | Hamster IgG |
| NEUT-579CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone 9H10) | FC, Block | Hamster IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0855 | Hi-Affi™ Rabbit Anti-CTLA4 Recombinant Antibody (clone DS855AB) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0157-FY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0157-FY) | Activ | Humanized IgG1, κ |
| HPAB-M0494-YC | Human Anti-CTLA4 Recombinant Antibody (HPAB-M0494-YC) | ELISA, FC, Block, FuncS | Human IgG1 |
| HPAB-M0495-YC | Human Anti-CTLA4 Recombinant Antibody (HPAB-M0495-YC) | ELISA, Block | Human IgG |
| FN-003CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone ANC152.2/8H5) | ELISA, FC, Block | Mouse IgG1, κ |
| HPAB-0270-YJ | Human Anti-CTLA4 Recombinant Antibody (clone CBC46YJ) | ELISA, FC, Block | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0749LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0749LY-F(E)) | FuncS, ELISA | Human Fab |
| HPAB-0750LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0750LY-F(E)) | FuncS, ELISA | Human Fab |
| HPAB-0751LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0751LY-F(E)) | FuncS, ELISA | Human Fab |
| HPAB-0752LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0752LY-F(E)) | FuncS, ELISA | Human Fab |
| HPAB-0753LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0753LY-F(E)) | FuncS, ELISA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-206 | Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ticilimumab (= Tremelimumab)), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0270-YJ-S(P) | Human Anti-CTLA4 Recombinant Antibody (clone CBC46YJ); scFv Fragment | ELISA, FC, Block | Human scFv |
| HPAB-1097-FY-F(E) | Hamster Anti-Ctla4 Recombinant Antibody (clone FY-002); scFv Fragment | ELISA | Hamster scFv |
| HPAB-1098-FY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-1098-FY-F(E)) | ELISA | Human Fab |
| HPAB-S0012-YC-S(P) | Human Anti-CTLA4 Recombinant Antibody (clone 11.2.1); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-S0013-YC-S(P) | Human Anti-CTLA4 Recombinant Antibody (clone 6.1.1); scFv Fragment | ELISA, Block | Human scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP860-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP860-YC) | ELISA, Block | Camel VHH |
| HPAB-AP861-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP861-YC) | ELISA, Block | Camel VHH |
| HPAB-AP862-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP862-YC) | ELISA, Block | Camel VHH |
| HPAB-AP863-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP863-YC) | ELISA, Block | Camel VHH |
| HPAB-AP864-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP864-YC) | ELISA, Block | Camel VHH |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AFC-TAB-067. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.