Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ipilimumab), ADCC Enhanced (CAT#: AFC-TAB-067)

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CTLA4. Ipilimumab (known as MDX-010 and MDX-101), marketed as Yervoy, is a drug used for the treatment of melanoma, a type of skin cancer. It is a U.S. Food and Drug Administration (FDA) approved human monoclonal antibody, and works by activating the immune system by targeting CTLA-4.
Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, there is also an inhibitory mechanism that interrupts this destruction. Ipilimumab turns off this inhibitory mechanism and allows CTLs to continue to destroy cancer cells.

Host: Human

Isotype: ADCC enhanced antibody

Applications: FuncS, IF, Neut, ELISA, FC


Specific Inquiry
  • Size:
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  • Purity:
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  • Gene Expression
  • Datasheet
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RNA Expression


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Clone
  • Ipilimumab
  • Applications
  • FuncS, IF, Neut, ELISA, FC
  • Conjugate
  • Unconjugated
  • Trade name
  • Yervoy
  • Generic Name
  • Ipilimumab
  • Related Disease
  • Melanoma, metastatic

Product Property

  • Purity
  • >95% by SDS-PAGE
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Ipilimumab; yervoy; 477202-00-9; MDX-010; MDX-101; Yervoy; MDX-010; MDX-101; CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3, CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3;

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Ipilimumab"

Anti-Human CTLA4 Recombinant Antibody (Ipilimumab)
Recombinant monoclonal antibody to CTLA4. Ipilimumab (known as MDX-010 and MDX-101), marketed as Yervoy, is a drug used for the treatment of melanoma, a type of skin cancer. It is a U.S. Food and Drug Administration (FDA) approved human monoclonal antibody, and works by activating the immune system by targeting CTLA-4.
Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, there is also an inhibitory mechanism that interrupts this destruction. Ipilimumab turns off this inhibitory mechanism and allows CTLs to continue to destroy cancer cells.

See other products for "CTLA4"

Human Antibody

CAT Product Name Application Type
TAB-067 Anti-Human CTLA4 Recombinant Antibody (Ipilimumab) WB, FuncS, IF, Neut, ELISA, FC, IP IgG1 - kappa
TAB-206 Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) WB, IF, IP, Neut, FuncS, ELISA, FC IgG2

Immunotoxin

CAT Product Name Application Type
AGTO-G015E Anti-CTLA4 immunotoxin (scFv)-PE Cytotoxicity assay, Function study
AGTO-G015S Anti-CTLA4 immunotoxin (scFv)-Sap Cytotoxicity assay, Function study
AGTO-G015M Anti-CTLA4 immunotoxin (scFv)-Mel Cytotoxicity assay, Function study

Rat Antibody

CAT Product Name Application Type
TAB-195CL Mouse Anti-CTLA4 Recombinant Antibody (TAB-195CL) ELISA Mouse IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-085MZ Anti-Human CTLA4 Recombinant Antibody (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-085MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-086MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-085MZ-F(E) Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-086MZ-F(E) Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2422.C) ELISA, FC Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-087MZ Mouse Anti-CTLA4 Recombinant Antibody (TAB-087MZ) ELISA Mouse IgG
TAB-087MZ-S(P) Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-087MZ-S(P)) ELISA Mouse scFv
TAB-089MZ-S(P) Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-089MZ-S(P)) ELISA Mouse scFv
TAB-090MZ-S(P) Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-090MZ-S(P)) ELISA Mouse scFv
TAB-093MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (Mu-26B) ELISA

Humanized Antibody

CAT Product Name Application Type
TAB-083MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.H) ELISA, FC Humanized antibody
TAB-084MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.H) ELISA, FC Humanized antibody
TAB-088MZ-S(P) Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-088MZ-S(P)) ELISA Human scFv
TAB-091MZ-S(P) Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-091MZ-S(P)) ELISA Human scFv
TAB-092MZ-S(P) Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-092MZ-S(P)) ELISA Human scFv

Neutralizing Antibody

CAT Product Name Application Type
NEUT-567CQ Mouse Anti-CTLA4 Recombinant Antibody (clone 14D3) FC, FuncS, Neut, IP, WB Mouse IgG2a, κ
NEUT-569CQ Mouse Anti-CTLA4 Recombinant Antibody (clone AS32) WB, Neut Mouse IgG1
NEUT-570CQ Human Anti-CTLA4 Recombinant Antibody (clone YC030) Neut Human IgG1, κ
NEUT-572CQ Hamster Anti-Ctla4 Recombinant Antibody (clone UC10-4B9) FC, Block, ELISA, IP Hamster IgG
NEUT-580CQ Rat Anti-Ctla4 Recombinant Antibody (clone CBL855) FC, Neut, WB Rat IgG2

Blocking Antibody

CAT Product Name Application Type
NEUT-568CQ Mouse Anti-CTLA4 Recombinant Antibody (clone L3D10) FC, Block Mouse IgG1, κ
NEUT-571CQ Mouse Anti-CTLA4 Recombinant Antibody (clone BN13) Block, FC Mouse IgG2a
NEUT-577CQ Hamster Anti-Ctla4 Recombinant Antibody (clone MAB0835) Block, FC Hamster IgG
NEUT-578CQ Hamster Anti-Ctla4 Recombinant Antibody (clone RYNmCTLA-4) Block Hamster IgG
NEUT-581CQ Hamster Anti-Ctla4 Recombinant Antibody (clone UC10-4F10-11) Block, FC, WB Hamster IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0855 Hi-Affi™ Rabbit Anti-CTLA4 Recombinant Antibody (clone DS855AB) WB Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0051-YC-F(E) Human Anti-CTLA4 Recombinant Antibody (clone 10D1); Fab Fragment ELISA, Cyt, Block Human Fab
HPAB-0157-FY-F(E) Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0157-FY-F(E)) Activ Humanized Fab
HPAB-N0343-YC-F(E) Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-N0343-YC-F(E)) FC, ELISA Human Fab
HPAB-0749LY-F(E) Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0749LY-F(E)) FuncS, ELISA Human Fab
HPAB-0750LY-F(E) Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0750LY-F(E)) FuncS, ELISA Human Fab

Recombinant Antibody

CAT Product Name Application Type
HPAB-N0343-YC Human Anti-CTLA4 Recombinant Antibody (HPAB-N0343-YC) FC, ELISA Human IgG1, κ
HPAB-0749LY Human Anti-CTLA4 Recombinant Antibody (HPAB-0749LY) FuncS, ELISA Human IgG
HPAB-0750LY Human Anti-CTLA4 Recombinant Antibody (HPAB-0750LY) FuncS, ELISA Human IgG
HPAB-0751LY Human Anti-CTLA4 Recombinant Antibody (HPAB-0751LY) FuncS, ELISA Human IgG
HPAB-0752LY Human Anti-CTLA4 Recombinant Antibody (HPAB-0752LY) FuncS, ELISA Human IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0767LY-S(P) Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-0767LY-S(P)) FuncS, ELISA Human scFv
HPAB-N0054-YC-S(P) Human Anti-CTLA4 Recombinant Antibody (clone 4H9-G5-D5-B1); scFv Fragment ELISA, FC Human scFv
HPAB-N0055-YC-S(P) Human Anti-CTLA4 Recombinant Antibody (clone 9B8-H2-B6-G5); scFv Fragment ELISA, FC Human scFv
HPAB-N0056-YC-S(P) Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (HPAB-N0056-YC-S(P)) ELISA, FuncS Humanized scFv
HPAB-S0013-YC-S(P) Human Anti-CTLA4 Recombinant Antibody (clone 6.1.1); scFv Fragment ELISA, Block Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-206 Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ticilimumab (= Tremelimumab)), ADCC Enhanced IF, IP, Neut, FuncS, ELISA ADCC enhanced antibody

Single-domain Antibody

CAT Product Name Application Type
HPAB-AP860-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP860-YC) ELISA, Block Camel VHH
HPAB-AP861-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP861-YC) ELISA, Block Camel VHH
HPAB-AP862-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP862-YC) ELISA, Block Camel VHH
HPAB-AP863-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP863-YC) ELISA, Block Camel VHH
HPAB-AP864-YC Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP864-YC) ELISA, Block Camel VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot

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