Human Anti-EGFR Recombinant Antibody (clone F4); scFv Fragment

CAT#: FAMAB-0094-YC-S(P)

Provided is a internalizing antibody directed against EGFR (epidermal growth factor receptor), a tyrosine kinase receptor that is overexpressed in a wide range of tumour cells. The clone F4 bound native EGFR-bearing cell lines and could be internalized, but did not bind EGFR-negative cell lines. F4 could be used to target therapeutic agents into tumour cells and was expected to be nonimmunogenic in humans.

Gene Expression
Figure 1 IF staining of human cell line A-431 Figure 2 IF staining of human cell line U-251 MG Figure 3 Colon Figure 4 Liver Figure 5 Kidney Figure 6 Testis Figure 7 Placenta Figure 8 Lymph node Figure 9 RNA cell line category: Cell line enriched (A-431)

Specifications

  • Host Species
  • Human
  • Derivation
  • Phage display library
  • Type
  • Human scFv
  • Specificity
  • Human EGFR
  • Species Reactivity
  • Human
  • Clone
  • F4
  • Related Disease
  • Tumor

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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