Mouse Anti-ICAM1 Recombinant Antibody (VS3-CJ411)
CAT#: VS3-CJ411
This product is a mouse antibody that recognizes ICAM1.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/29_G3_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2142/203_G3_1_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line EFO-21
Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/1937_A10_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line GAMG
Immunofluorescent staining of human cell line GAMG shows localization to plasma membrane, vesicles, nucleoplasm & centrosome.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/2058_A10_4_blue_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/7230_B_9_5.jpg
Normal Tissue
Figure 6 Lung
Alveolar cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2126/7230_A_3_4.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_8_3.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_8_5.jpg
Normal Tissue
Figure 9 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4877/13410_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (HHSteC, Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000090339-ICAM1
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Specifications
- Immunogen
- KLH-conjugated synthetic peptide encompassing a sequence within human CD54
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human ICAM1
- Species Reactivity
- Human
- Applications
- WB, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Immunogen affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.2% BSA, PBS.
- Preservative
- 0.01% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500-1:1000), Immunohistochemistry (1:100-1:300).
Target
- Alternative Names
- Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD antigen CD54; BB2; CD54; P3.58
- Gene ID
- 3383
- UniProt ID
- P05362
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. ICAM family.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
- Protein Refseq
- NP_000192.2
- Function
- ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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| TAB-121CT-S(P) | Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (MD-2) | ELISA, FC | Human antibody |
| TAB-122CT-S(P) | Anti-Human ICAM-1 Recombinant Antibody scFv Fragment (R6-5-D6) | ELISA, FC | Human antibody |
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| TAB-121CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (MD-2) | ELISA, FC | Human antibody |
| TAB-122CT-F(E) | Anti-Human ICAM-1 Recombinant Antibody Fab Fragment (R6-5-D6) | ELISA, FC | Human antibody |
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| NEUT-925CQ | Mouse Anti-ICAM1 Recombinant Antibody (NEUT-925CQ) | FC, FuncS, IHC, Neut, WB | Mouse IgG1, κ |
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| CAT | Product Name | Application | Type |
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| NEUT-924CQ | Mouse Anti-ICAM1 Recombinant Antibody (clone HCD54) | FC, IF, Block | Mouse IgG1, κ |
| NEUT-928CQ | Mouse Anti-ICAM1 Recombinant Antibody (VMC183) | Block, FC, IHC, IP | Mouse IgG1 |
| NEUT-929CQ | Mouse Anti-ICAM1 Recombinant Antibody (NEUT-929CQ) | Block, WB, IP, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1723 | Rabbit Anti-ICAM1 Recombinant Antibody (clone DS1723AB), Biotin | IHC-Fr, IP, WB, ELISA | Rabbit IgG |
| MOR-1724 | Rabbit Anti-Icam1 Recombinant Antibody (clone DS1724AB) | ELISA | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0053-YC-F(E) | Human Anti-ICAM1 Recombinant Antibody Fab Fragment (HPAB-0053-YC-F(E)) | FC, IP | Human Fab |
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| HPAB-1729-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody (clone LAC3040); Fab Fragment | ELISA | Human Fab |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0043-FY-S(P) | Human Anti-ICAM1 Recombinant Antibody scFv Fragment (HPAB-0043-FY-S(P)) | ELISA | Human scFv |
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| HPAB-1728-FY-F(E) | Human Anti-ICAM1 Recombinant Antibody (clone LAC1555); scFv Fragment | ELISA | Human scFv |
| HPAB-1729-FY-F(E) | Human Anti-ICAM1 Recombinant Antibody (clone LAC3040); scFv Fragment | ELISA | Human scFv |
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