B*27:05/Human BRAF (600V) (GRFGLATVK) MHC Pentamer (CAT#: MHC-YF342)

• Allele
• B*27:05

• Class
• Class I

• MHC Species
• Human

• Antigen
• BRAF (600V)

• Antigen Species
• Human

• Peptide
• GRFGLATVK

• Range
• 594-601

• Conjugate
• Unlabeled, Biotin, R-PE, APC

• Application
• FCM

• Antigen Introduction
• This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

• Alternative Names
• B-Raf Proto-Oncogene, Serine/Threonine Kinase; V-Raf Murine Sarcoma Viral Oncogene Homolog B1; V-Raf Murine Sarcoma Viral Oncogene Homolog B; Proto-Oncogene B-Raf; BRAF1; RAFB1; B-Raf Proto-Oncogene Serine/Threonine-Protein Kinase (P94); Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; Serine/Threonine-Protein Kinase B-Raf;

• Gene ID
• 673

• UniProt ID
• P15056

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