Recombinant Human Anti-MAPT Antibody (clone Tilavonemab) (CAT#: VS-0923-FY255)
Tilavonemab is a humanized IgG4 antibody that was developed by C2N Diagnostics and AbbVie to treat tauopathies. It specifically targets an aggregated, extracellular form of pathological tau by binding to amino acids 25-30 in tau's N-terminus. By blocking the uptake of tau aggregates in human and mouse neurons, Tilavonemab effectively reduces brain atrophy. This particular form of tau is believed to play a role in the transneuronal propagation of tau pathology in cell-based and mouse models, potentially explaining the characteristic progression of tau pathology in Alzheimer's disease.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nuclear speckles & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48895/1070_E6_2_selected.jpg
Figure 2 IF staining of human cell line BJ
(Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
(Immunohistochemical staining of human appendix shows strong positivity in peripheral ganglia and nerve fibers.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69524/156431_A_3_2_selected.jpg
Figure 3 Cerebral cortex
(Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
(Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_B_8_5.jpg
Figure 4 Colon
(Endocrine cells
Staining:
Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
(Endocrine cells
Staining:
Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_3.jpg
Figure 5 Kidney
(Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
(Proximal tubules (cell body)
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/151/156500_A_7_5.jpg
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
Figure 6 RNA cell line category: Group enriched (HDLM-2, SCLC-21H, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186868-MAPT
Specifications
- Host Species
- Human
- Type
- Human IgG4, kappa
- Specificity
- Human MAPT
- Species Reactivity
- Human, Mouse
- Clone
- Tilavonemab
- Applications
- Block
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Microtubule Associated Protein Tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Protein Phosphatase 1, Regulatory Subunit 103; Neurofibrillary Tangle Protein; Paired Helical Filament-Tau; PHF-Tau; MAPTL; MTBT1; TAU; ABBV-8E12, C2N 8E12, HJ8.5
- Gene ID
- 4137
- UniProt ID
- P10636
Recommended Products
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-340 | Mouse Anti-MAPT Recombinant Antibody (clone AT8); Fab Fragment | ELISA, FuncS | Mouse Fab |
| NS-090CN-F(E) | Mouse Anti-MAPT Recombinant Antibody; Fab Fragment (NS-090CN-F(E)) | WB, ELISA, IHC, IP | Mouse Fab |
| HPAB-N0170-YC-F(E) | Human Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-N0170-YC-F(E)) | ELISA, Inhib | Humanized Fab |
| HPAB-N0171-YC-F(E) | Human Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-N0171-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-N0172-YC-F(E) | Mouse Anti-MAPT Recombinant Antibody; Fab Fragment (HPAB-N0172-YC-F(E)) | ELISA | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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