EGFR & CD28

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

EGFR encodes a receptor tyrosine kinase that is involved in the regulation of cell growth, survival, and differentiation. It is activated by binding to its ligands, such as epidermal growth factor (EGF), and mediates downstream signaling pathways that control cellular processes like proliferation, migration, and differentiation. EGFR is critical in normal development, wound healing, and tissue repair. However, mutations or overexpression of EGFR are associated with various cancers, including non-small cell lung cancer (NSCLC), making EGFR a target for cancer therapies, including monoclonal antibodies and tyrosine kinase inhibitors.