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EGFR & CD28

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Anti-EGFR & CD28 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


CD28 is a co-stimulatory receptor found on T cells that plays a key role in T-cell activation and survival. It is a transmembrane protein expressed on naïve and activated T cells, binding to B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells (APCs). This interaction provides the necessary secondary signal for full T-cell activation, alongside T-cell receptor (TCR) engagement with antigen-presenting major histocompatibility complex (MHC). CD28 signaling promotes cytokine production, T-cell proliferation, and survival. In the absence of CD28 signaling, T cells may become anergic (non-responsive). Because of its role in immune regulation, CD28 is a target for therapeutic interventions in autoimmune diseases, transplantation, and cancer immunotherapy.
EGFR & CD28
EGFR encodes a receptor tyrosine kinase that is involved in the regulation of cell growth, survival, and differentiation. It is activated by binding to its ligands, such as epidermal growth factor (EGF), and mediates downstream signaling pathways that control cellular processes like proliferation, migration, and differentiation. EGFR is critical in normal development, wound healing, and tissue repair. However, mutations or overexpression of EGFR are associated with various cancers, including non-small cell lung cancer (NSCLC), making EGFR a target for cancer therapies, including monoclonal antibodies and tyrosine kinase inhibitors.
EGFR & CD28
Related Diseases
Bladder Cancer Bladder Cancer
Non-small Cell Lung Cancer Non-small Cell Lung Cancer
Pancreatic Cancer Pancreatic Cancer
Rheumatoid Arthritis Rheumatoid Arthritis
Systemic Lupus Erythematosus Systemic Lupus Erythematosus
Hepatocellular Carcinoma Hepatocellular Carcinoma
Allograft Rejection Allograft Rejection
Autoimmune Thyroid Disease Autoimmune Thyroid Disease
Graft-versus-Host Disease Graft-versus-Host Disease
Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young
Cushing Syndrome Cushing Syndrome
Related Signaling Pathways
JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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