Afuco™ Anti-Human IL18 ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-388CL)
Anti-IL18 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. AFC-388CL is a humanised IgG1/kappa antibody which is directed against the soluble cytokine interleukin-18 (IL-18). AFC-388CL was generally well tolerated. The most common AEs were nasopharyngitis and headache, arising as frequently in the placebo as in the active drug groups; most AEs were mild to moderate and unrelated to dose level. There were no allergic, delayed-type hypersensitivity, or infusion-related reactions and the incidence of immunogenicity was low.
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Figure 1 Mean plasma glucose levels revealed several apparent improvements in glucose control, as determined by reductions in FPG, in a number of patients dosed with placebo and doses of GSK1070806 up to Day 85.
McKie, E. A., Reid, J. L., Mistry, P. C., DeWall, S. L., Abberley, L., Ambery, P. D., & Gil-Extremera, B. (2016). A study to investigate the efficacy and safety of an anti-interleukin-18 monoclonal antibody in the treatment of type 2 diabetes mellitus. PLoS One, 11(3), e0150018.
Figure 2 With the exception of insulin and C-peptide at one time point (0.25 mg/kg vs placebo on Day 29), there were also no statistically significant effects of GSK1070806 doses on glucose, insulin and C-peptide weighted mean AUC(0–4 hours) over placebo on Days 29, 57, and 85.
McKie, E. A., Reid, J. L., Mistry, P. C., DeWall, S. L., Abberley, L., Ambery, P. D., & Gil-Extremera, B. (2016). A study to investigate the efficacy and safety of an anti-interleukin-18 monoclonal antibody in the treatment of type 2 diabetes mellitus. PLoS One, 11(3), e0150018.
Figure 3 Assessment of the mean change from baseline shows evidence of a reduction in HbA1c percent up to Day 85 with subjects dosed with GSK1070806 5 mg/kg compared with placebo, although the data are highly variable.
McKie, E. A., Reid, J. L., Mistry, P. C., DeWall, S. L., Abberley, L., Ambery, P. D., & Gil-Extremera, B. (2016). A study to investigate the efficacy and safety of an anti-interleukin-18 monoclonal antibody in the treatment of type 2 diabetes mellitus. PLoS One, 11(3), e0150018.
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Crohn's Disease; Diabetes Type 2; Ulcerative Colitis
Product Property
- Purity
- >95% as determined by analysis by RP-HPLC
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- IL18; interleukin 18; IGIF; IL-18; IL-1g; IL1F4; interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor)
- Gene ID
- 3606
- UniProt ID
- A0A024R3E0
Related Resources
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1332z | Mouse Anti-IL18 Recombinant Antibody (clone 27G4) | WB, IF, ELISA | Mouse IgG2b |
| HPAB-0064-YC | Human Anti-IL18 Recombinant Antibody (clone 2E1) | ELISA, RIA, IHC, FuncS, Neut | Human IgG |
| HPAB-0065-YC | Human Anti-IL18 Recombinant Antibody (clone LT28) | ELISA, RIA, IHC, FuncS, Neut | Human IgG |
| FAMAB-1199CQ | Mouse Anti-IL18 Recombinant Antibody (clone SAIC-24B-4) | Immuno-MRM, ELISA | Mouse IgG1 |
| VS3-FY748 | Recombinant Rabbit Anti-IL18 Antibody (clone R02-8B2) | WB, IHC-P | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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