Anti-RAS Intrabody [(D-Arg)9] (IAB-B009(A))

Recombinant anti-RAS intrabody linked to (D-Arg)9 works within cells to bind human RAS, expressed in E. coli cells. An intracellular antibody constructed by the single chain antibody can inhibit proliferations and invasion abilities of the human tumor cells with highly expressed p21ras proteins.      

human Kirsten rat sarcoma viral oncogene homolog
Cell Penetrating Peptide
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
Can be useful in applications such as: Western blot; Coimmunopricipation; Functional studies
Alternative Names
KRAS; Kirsten rat sarcoma viral oncogene homolog; NS; NS3; CFC2; KRAS1; KRAS2; RASK2
Entrez Gene ID
UniProt ID

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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