Recombinant Anti-human RAS Intrabody [(D-Arg)9]
CAT#: IAB-B009(A)
Recombinant anti-RAS intrabody linked to (D-Arg)9 works within cells to bind human RAS, expressed in E. coli cells. An intracellular antibody constructed by the single chain antibody can inhibit proliferations and invasion abilities of the human tumor cells with highly expressed p21ras proteins.
Specifications
- Immunogen
- human Kirsten rat sarcoma viral oncogene homolog
- Host Species
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Can be useful in applications such as: Western blot; Coimmunopricipation; Functional studies
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
- Alternative Names
- KRAS; Kirsten rat sarcoma viral oncogene homolog; NS; NS3; CFC2; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; GTPase KRas; K-Ras 2; c-Ki-ras; oncogene KRAS2; K-ras p21 protein; c-Kirsten-ras protein; PR310 c-K-ras oncogene; tr
- Gene ID
- 3845
- UniProt ID
- A0A024RAV5
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Related Signaling Pathways
BCR Signaling Pathway
cAMP Signaling Pathway
ErbB Signaling Pathway
FcεR1 Signaling Pathway
JAK-STAT Signaling Pathway
MAPK Signaling Pathway
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
Ras Signaling Pathway
TCR Signaling Pathway
Related Diseases
Bladder Cancer
Breast Cancer
Colorectal Cancer
Endometrial Cancer
Gastric Cancer
Non-small Cell Lung Cancer
Pancreatic Cancer
Prostate Cancer
Throid Cancer
Endocrine Resistance
Hepatocellular Carcinoma
Insulin Resistance
Alcoholism
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "RAS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B009(G) | Recombinant Anti-human RAS Intrabody [+36 GFP] | IF, ELISA, FuncS | scFv-(+36GFP) |
| IAB-B009(T) | Recombinant Anti-human RAS Intrabody [Tat] | FC, IF, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3006 | Hi-Affi™ Recombinant Rabbit Anti-Ras Monoclonal Antibody (DS3006AB) | WB, ICC, IF | IgG |
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