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Tomuzotuximab (TAB-464CQ)

Recombinant monoclonal antibody to EGFR. Tomuzotuximab is a chimeric monoclonal antibody that can be potentially used in the treatment of Cancers, head and neck, Solid tumors.      

  • Published Data
  • Datasheet

Figure 1 Concentration-time profiles of repeated weekly infusions of (A) 720 mg and (B) 990 mg tomuzotuximab measured in individual patients before and at the end of infusion.

The dotted line indicates the 50 µg/mL trough level. Tomuzotuximab serum levels were above 50 µg/mL 1 week after the second infusion in four out of five patients who received 720 mg and 1 week after the first infusion in all three patients who received 900 mg tomuzotuximab.

Fiedler, W., Cresta, S., Schulze-Bergkamen, H., De Dosso, S., Weidmann, J., Tessari, A., ... & Zurlo, A. (2018). Phase I study of tomuzotuximab, a glycoengineered therapeutic antibody against the epidermal growth factor receptor, in patients with advanced carcinomas. ESMO open, 3(2), e000303.


Specifications
Immunogen
The details of the immunogen for this antibody are not available.
Host
Human
Derivation
Chimeric
Type
IgG1, κ
Specificity
Human EGFR
Species Reactivity
Human
Applications
ELISA, IHC, FC, IP, IF, FuncS
Conjugate
Unconjugated
CAS NO.
1646321-00-7
Generic Name
Tomuzotuximab
UNII
5P637IXG16
Related Disease
Cancers, head and neck, Solid tumors
Applications
Application Notes
The EGFR antibody has been reported in applications of PK.
Target
Alternative Names
Epidermal Growth Factor Receptor 2; Receptor Tyrosine-Protein Kinase ErbB-1; Erb-B2 Receptor Tyrosine Kinase 1; Proto-Oncogene C-ErbB-1; EC 2.7.10.1; ERBB1; ERBB; HER1
Entrez Gene ID
1956
UniProt ID
P00533

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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