This product is a human antibody targeting human HGF and has no binding to human VEGF.
Figure 1. Mechanism of action of 2.12.1 on U-87 MG tumor xenografts: U-87 MG cells were injected s.c. in the right flank of female nude mice (n = 10).
Representative, high-magnification images of BrdUrd-positive cells (brown) in U-87 MG tumors 24 hours after 2.12.1 (B) treatment.
Burgess, T., Coxon, A., Meyer, S., Sun, J., Rex, K., Tsuruda, T., ... & McDorman, K. (2006). Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met–dependent human tumors. Cancer research, 66(3), 1721-1729.
Figure 2. Anti-HGF antibodies completely inhibit HGF/c-Met.
Anti-HGF antibodies neutralize HGF/c-Met binding. The percentage inhibition of HGF/c-Met binding was measured over a 10-point dose response of each antibody using a solid phase binding assay.
Burgess, T., Coxon, A., Meyer, S., Sun, J., Rex, K., Tsuruda, T., ... & McDorman, K. (2006). Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met–dependent human tumors. Cancer research, 66(3), 1721-1729.
Figure 3. Anti-HGF antibodies neutralize HGF-mediated cellular functions.
Representative fields of MDA-MB-435 cells that migrated to the bottom of the Matrigel-coated filter were imaged using epifluorescence illumination and a low-power objective.
Burgess, T., Coxon, A., Meyer, S., Sun, J., Rex, K., Tsuruda, T., ... & McDorman, K. (2006). Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met–dependent human tumors. Cancer research, 66(3), 1721-1729.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-080 | Human Anti-HGF Recombinant Antibody (TAB-080) | WB, ELISA, FC, IP, FuncS, IF, Neut | Human IgG2, κ |
TAB-076CT | Anti-Human HGF/SF Recombinant Antibody (2C3) | ELISA, WB | Human antibody |
TAB-076CT-S(P) | Anti-Human HGF/SF Recombinant Antibody scFv Fragment (2C3) | ELISA, WB | Human antibody |
TAB-076CT-F(E) | Anti-Human HGF/SF Recombinant Antibody Fab Fragment (2C3) | ELISA, WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-749 | Anti-HGF Recombinant Antibody (Ficlatuzumab) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
TAB-075CT | Human Anti-HGF Recombinant Antibody (TAB-075CT) | ELISA, Neut | Humanized antibody |
TAB-075CT-S(P) | Human Anti-HGF Recombinant Antibody; scFv Fragment (TAB-075CT-S(P)) | ELISA, Neut | Humanized scFv |
TAB-075CT-F(E) | Human Anti-HGF Recombinant Antibody; Fab Fragment (TAB-075CT-F(E)) | ELISA, Neut | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-132 | Rabbit Anti-HGF Recombinant Antibody (PABL-132) | WB, ELISA, FuncS | Rabbit IgG |
MOB-0899CT | Recombinant Mouse anti-Human HGF Monoclonal antibody (0.O.437) | ELISA, IP, WB | |
HPAB-0991WJ | Human Anti-HGF Recombinant Antibody (clone LRMR2B8) | ELISA | Human IgG1 |
HPAB-1856-FY | Human Anti-HGF Recombinant Antibody (HPAB-1856-FY) | Inhib | Human IgG2 |
HPAB-1857-FY | Human Anti-HGF Recombinant Antibody (HPAB-1857-FY) | Inhib | Human IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-132 | Rabbit Anti-HGF Recombinant Antibody; scFv Fragment (PSBL-132) | WB, ELISA, FuncS | Rabbit scFv |
HPAB-0651-CN-S(P) | Mouse Anti-HGF Recombinant Antibody; scFv Fragment (HPAB-0651-CN-S(P)) | ELISA, Neut | Mouse scFv |
HPAB-0652-CN-S(P) | Mouse Anti-HGF Recombinant Antibody; scFv Fragment (HPAB-0652-CN-S(P)) | ELISA, Neut | Mouse scFv |
HPAB-0653-CN-S(P) | Mouse Anti-HGF Recombinant Antibody; scFv Fragment (HPAB-0653-CN-S(P)) | ELISA, Neut | Mouse scFv |
HPAB-0654-CN-S(P) | Mouse Anti-HGF Recombinant Antibody; scFv Fragment (HPAB-0654-CN-S(P)) | ELISA, Neut | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-078CT | Llama Anti-HGF Recombinant Single Domain Antibody (TAB-078CT) | Block | Llama VHH |
HPAB-0993WJ | Recombinant Camelid Anti-HGF Single Domain Antibody (HGF13) | ELISA | Camelid VHH |
HPAB-0994WJ | Recombinant Human Anti-HGF Antibody (HGF13hum5) | ELISA | Humanized sdAb |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-900CQ | Mouse Anti-HGF Recombinant Antibody (clone 24612.111) | ELISA, WB, Neut | Mouse IgG1 |
NEUT-901CQ | Mouse Anti-HGF Recombinant Antibody (clone 5D20) | WB, Neut | Mouse IgG1 |
NEUT-902CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL070) | Neut, WB | Mouse IgG1 |
NEUT-903CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL435) | WB, Neut | Mouse IgG1 |
NEUT-904CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL1017) | Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1591 | Rabbit Anti-HGF Recombinant Antibody (clone DS1591AB) | ELISA | Rabbit IgG |
MOR-4217 | Rabbit Anti-HGF Recombinant Antibody (clone SI296DS) | ELISA | Rabbit IgG |
MOR-4585 | Rabbit Anti-HGF Recombinant Antibody (clone TH98DS) | WB, IF, ICC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-130 | Afuco™ Anti-HGF ADCC Recombinant Antibody (Flanvotumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-749 | Afuco™ Anti-HGF ADCC Recombinant Antibody (Ficlatuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-080 | Afuco™ Anti-HGF Recombinant Antibody (AFC-TAB-080), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0713-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone AB012); Fab Fragment | ELISA | Mouse Fab |
HPAB-0821-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone S265109B10); Fab Fragment | Neut, ELISA | Mouse Fab |
HPAB-0822-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone S260115C11); Fab Fragment | Neut, ELISA | Mouse Fab |
HPAB-0823-FY-S(P) | Human Anti-HGF Recombinant Antibody (clone S260105B02); Fab Fragment | Neut, ELISA | Chimeric (mouse/human) Fab |
HPAB-1856-FY-S(P) | Human Anti-HGF Recombinant Antibody; scFv Fragment (HPAB-1856-FY-S(P)) | ELISA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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