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BCMA & CD3

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Anti-BCMA & CD3 Products

  • BAFF-PE immunotoxin (AGTO-L075E)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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  • BAFF-DT immunotoxin (AGTO-L075D)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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  • TRX4 (Gly-002CL)
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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.
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