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EGFR & FcγRIII

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Anti-EGFR & FcγRIII Recombinant Antibody Products

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The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
EGFR & FcγRIII
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Related Diseases
Bladder Cancer Bladder Cancer
Non-small Cell Lung Cancer Non-small Cell Lung Cancer
Pancreatic Cancer Pancreatic Cancer
Hepatocellular Carcinoma Hepatocellular Carcinoma
Cushing Syndrome Cushing Syndrome
Related Signaling Pathways
JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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