What are the antibody's preservation conditions?

For long-term storage, the antibody should be kept at -20°C or -80°C. It can be stored at 4°C for brief usage.

What is this antibody's level of purity?

SDS-PAGE and HPLC analysis are commonly used to verify that the antibody has been purified to higher than 95% homogeneity.

Can research on medication development make use of this antibody?

In early research and development, it is appropriate for antiviral medication targeting and neutralization studies.

Anti-Human APP Recombinant Antibody (3H3)

CAT#: TAB-0801CLV

The anti-amyloid beta antibody 3H3 is a naturally occuring human IgG that can recognize a conformational epitope. The specific antibody can be used in the treatment of Alzheimer's Disease, family Danish dementia and other amyloid diseases.

Published Data Gene Expression

IHC

Figure 1 3H3 scFv expression prevents development of pathology in ADan-transgenicmice.

Newborn ADan-transgenicmice were injected into cerebral ventricles with pAAV- 3H3scFv and killed at 12 months of age.

Levites, Y., O'Nuallain, B., Puligedda, R. D., Ondrejcak, T., Adekar, S. P., Chen, C., ... & Walsh, D. M. (2015). A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. Journal of Neuroscience, 35(16), 6265-6276.

FuncS

Figure 2 mAb 3H3 is pan-reactive against immobilized Aconformers but insolution only recognizes aggregated peptide.

Antibody binding curves for 3H3 demonstrate the antibody's low nM reactivity with plate-immobilized Aconformers, 2-fold weaker binding to the monomeric peptide.

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Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg

RNA Expression Figure 5 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP

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Specifications

Host Species
Human

Derivation
Memory B cell

Type
Fully human antibody

Specificity
Human

Clone
3H3

Applications
IHC, FuncS

Related Disease
Alzheimer's disease

Applications

Application Notes
The APP antibody has been reported in applications of Immunohistochemistry, Functional Assay.

Target

Alternative Names
APP; Amyloid Beta; amyloid beta (A4) precursor protein

Gene ID
351

UniProt ID
P05067

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Breast cancer biomarkers at key points during disease progression

No Non-Determinative Binding

This antibody performed admirably in a variety of settings, such as flow cytometry and Western blot. Its adaptability is a major benefit.

Repeatable Outcomes

Every time we've utilized this antibody, the findings have been dependable and consistent. It is now an essential component of our study.

Easy-to-use

Our data quality was much enhanced by the absence of non-specific bands in our Western blots.

Q&As

What are the antibody's preservation conditions?

A: For long-term storage, the antibody should be kept at -20°C or -80°C. It can be stored at 4°C for brief usage.
What is this antibody's level of purity?

A: SDS-PAGE and HPLC analysis are commonly used to verify that the antibody has been purified to higher than 95% homogeneity.
Can research on medication development make use of this antibody?

A: In early research and development, it is appropriate for antiviral medication targeting and neutralization studies.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-0801CLV.pdf

MSDS

MSDS - TAB-0801CLV.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Clone 3H3"

CAT
Product Name

See other products for "APP"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-0019CL-VHH	Camelid Anti-APP Recombinant Antibody (TAB-0019CL-VHH)	IHC, WB	Camelid VHH
TAB-0020CL-VHH	Anti-Human APP VHH Single Domain Antibody (TAB-0020CL-VHH)	ELISA, IHC	Single domain antibody
TAB-0021CL-VHH	Anti-Human APP VHH Single Domain Antibody (TAB-0021CL-VHH)	ELISA, In vivo, FuncS	Single domain antibody
TAB-0022CL-VHH	Anti-Human APP VHH Single Domain Antibody (TAB-0022CL-VHH)	ELISA, In vivo, FuncS	Single domain antibody
HPAB-1136-CN-VHH	Camelid Anti-APP Recombinant Antibody (HPAB-1136-CN-VHH)	WB, ELISA, IHC	Camelid VHH

CAT	Product Name	Application	Type
TAB-252CQ	Mouse Anti-APP Recombinant Antibody (TAB-252CQ)	ELISA	Mouse IgG1
TAB-255CQ	Mouse Anti-APP Recombinant Antibody (TAB-255CQ)	WB	Mouse IgG
TAB-255CQ-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-255CQ-S(P))	ELISA	Mouse scFv
TAB-0764CLV-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0764CLV-F(E))	ELISA	Mouse Fab
TAB-0765CLV-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (TAB-0765CLV-F(E))	ELISA	Mouse Fab

CAT	Product Name	Application	Type
TAB-254CQ-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-254CQ-S(P))	ELISA	Mouse scFv
TAB-254CQ-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-254CQ-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-0802CLV-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-0802CLV-F(E))	ELISA	Chimeric (mouse/human) Fab
TAB-0789CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0789CLV-S(P))	ELISA	Mouse scFv
TAB-0802CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0802CLV-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
TAB-253CQ-F(E)	Human Anti-APP Recombinant Antibody; Fab Fragment (TAB-253CQ-F(E))	ELISA	Humanized Fab
TAB-0790CLV-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0790CLV-S(P))	ELISA	Humanized scFv
TAB-0828CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0828CLV-S(P))	ELISA	Mouse scFv
TAB-0829CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0829CLV-S(P))	ELISA	Mouse scFv
TAB-0830CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0830CLV-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
TAB-0783CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0783CLV-S(P))	ELISA, FuncS	Human scFv
TAB-0784CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0784CLV-S(P))	ELISA	Human scFv
TAB-0785CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0785CLV-S(P))	ELISA	Human scFv
TAB-0786CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0786CLV-S(P))	ELISA	Human scFv
TAB-0815CLV-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (TAB-0815CLV-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
MOB-0071MZ	Mouse Anti-APP Recombinant Antibody (clone CDI912)	WB, ICC, ELISA	Mouse IgG1
HPAB-0241-FY	Mouse Anti-APP Recombinant Antibody (HPAB-0241-FY)	Inhib, FuncS	Mouse IgG1
HPAB-0242-FY	Human Anti-APP Recombinant Antibody (HPAB-0242-FY)	WB	Humanized IgG1
HPAB-0970-FY	Mouse Anti-APP Recombinant Antibody (HPAB-0970-FY)	ELISA	Mouse IgG
HPAB-0971-FY	Mouse Anti-APP Recombinant Antibody (HPAB-0971-FY)	ELISA	Mouse IgG

CAT	Product Name	Application	Type
BRD-0685MZ	Chicken Anti-APP Polyclonal IgY	IHC	Chicken antibody

CAT	Product Name	Application	Type
PABX-014	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204)	WB, ELISA, FuncS	Rabbit IgG
PABX-014-F (E)	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone M204); Fab Fragment	WB, ELISA, FuncS	Rabbit Fab
MOR-0220	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone DS220AB)	ELISA, WB	Rabbit IgG
MOR-4539	Hi-Affi™ Rabbit Anti-APP Recombinant Antibody (clone TH47DS)	IHC-P, ELISA	Rabbit IgG
MOR-0082-FY	Rabbit Anti-APP Recombinant Antibody (clone AFY0053)	ICC, IHC-P, WB	Rabbit IgG

CAT	Product Name	Application	Type
EPAF-0566CQ	Mouse Anti-APP Recombinant Antibody (clone 6E10)	ELISA	Mouse IgG
EPAF-0567CQ	Mouse Anti-APP Recombinant Antibody (clone 4G8)	ELISA, IHC	Mouse IgG2b
EPAF-0568CQ	Human Anti-APP Recombinant Antibody (clone HyL5)	ELISA, Inhib	Human IgM
EPAF-0569CQ	Mouse Anti-APP Recombinant Antibody (clone AB1-42)	IHC	Mouse IgG
EPAF-0570CQ	Human Anti-APP Recombinant Antibody (clone L11.3)	IHC, ELISA, Inhib	Human IgM

CAT	Product Name	Application	Type
NS-001CN	Human Anti-APP Recombinant Antibody (clone AS)	WB	Human IgG
NS-007CN	Mouse Anti-APP Recombinant Antibody (NS-007CN)	ELISA, FuncS	Mouse IgG1
NS-001CN-F(E)	Human Anti-APP Recombinant Antibody (clone AS); Fab Fragment	WB	Human Fab
NS-007CN-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (NS-007CN-F(E))	ELISA	Mouse Fab
NS-001CN-S(P)	Human Anti-APP Recombinant Antibody (clone AS); scFv Fragment	WB	Human scFv

CAT	Product Name	Application	Type
HPAB-0176-FY-F(E)	Mouse Anti-APP Recombinant Antibody; Fab Fragment (HPAB-0176-FY-F(E))	AG	Mouse Fab, κ
PFBC-394	Mouse Anti-APP Recombinant Antibody (clone c#6); Fab Fragment	ELISA, WB, FuncS	Mouse Fab
PFBC-395	Mouse Anti-APP Recombinant Antibody (clone c#24); Fab Fragment	ELISA, WB, FuncS	Mouse Fab
HPAB-0255-YJ-F(E)	Human Anti-APP Recombinant Antibody (clone CBA45YJ); Fab Fragment	ELISA, WB, Inhib, FuncS	Human Fab
HPAB-0345-YJ-F(E)	Human Anti-APP Recombinant Antibody (clone B6); Fab Fragment	ELISA, Inhib, WB	Human Fab

CAT	Product Name	Application	Type
HPAB-0116CQ-S(P)	Mouse Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0116CQ-S(P))	ELISA, WB, IP, FuncS	Mouse scFv
HPAB-0117CQ-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0117CQ-S(P))	ELISA, WB, IP, FuncS	Human scFv
HPAB-0118CQ-S(P)	Human Anti-APP Recombinant Antibody (clone Fv1E4); scFv Fragment	ELISA, Inhib	Human scFv
HPAB-0119CQ-S(P)	Human Anti-APP Recombinant Antibody (clone h12A11v1); scFv Fragment	ELISA, FuncS	Human scFv
HPAB-0120CQ-S(P)	Human Anti-APP Recombinant Antibody; scFv Fragment (HPAB-0120CQ-S(P))	ELISA, IHC, FuncS	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-225	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-225)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-228	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-228)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody
AFC-TAB-229	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-229)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
AFC-TAB-227	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227)	ELISA, IP, FC, FuncS, Neut	ADCC enhanced antibody
AFC-TAB-226	Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-226)	IF, IP, Neut, FuncS, ELISA	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-0008-YJ	Mouse Anti-APP Recombinant Antibody (clone 508F)	ELISA	Mouse IgM

CAT	Product Name	Application	Type
VS-0424-XY17	AbPlus™ Anti-APP Magnetic Beads (DE2B4)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-1024-XY23	Mouse Anti-NHP APP Recombinant Antibody (VS-1024-XY23)	WB, ICC	Mouse IgG1

CAT	Product Name	Application	Type
VS-0325-FY6	Human Anti-APP (clone 2A7) scFv-Fc Chimera	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC204	Recombinant Anti-APP Vesicular Antibody, EV Displayed (VS-0425-YC204)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application
VS-0525-XY469	Anti-APP Immunohistochemistry Kit	IHC
VS-0525-XY470	Anti-Mouse APP Immunohistochemistry Kit	IHC
VS-0525-XY471	Anti-Monkey APP Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC2	Recombinant Anti-APP Biparatopic Antibody, Tandem sdAb	ELISA, Inhib	Tandem sdAb
VS-0525-YC18	Recombinant Anti-APP (AA 3-7 x AA 12-28) Biparatopic Antibody, Tandem scFv (Clone h12A11v1 x Solanezumab)	ELISA, Neut, FC, IF, IP, WB	Tandem scFv
VS-0525-YC196	Recombinant Anti-APP (AA 1-5 x AA 13-28) Biparatopic Antibody, Tandem scFv	ELISA, FC, IF, IP, Neut, WB	Tandem scFv
VS-0525-YC198	Recombinant Anti-APP (AA 13-28 x AA 33-40) Biparatopic Antibody, Tandem scFv (Solanezumab x Ponezumab)	ELISA, FC, IF, IP, Neut, WB	Tandem scFv

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