Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
  • Home
  • ERBB3
  • Rabbit Anti-ERBB3 Recombinant Antibody (clone R04-8J6)

Rabbit Anti-ERBB3 Recombinant Antibody (clone R04-8J6) (CAT#: VS3-XY3348)

It is a recombinant rabbit antibody targeting the human ERBB3 (erb-b2 receptor tyrosine kinase 3), which involves in the regulation of myeloid cell differentiation. This antibody reacts with human and rat ERBB3. It has been determined using Western Blot and Immunoprecipitation. The recommended dilutions of Western Blot and Immunoprecipitation is 1/500-1/1000 and 1/20, respectively.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Formats:
  • Isotype Switching:
  • Fc Engineering:
  • Modalities:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & actin filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/if_selected.jpg
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/ihc_selected.jpg
Figure 3 IHC staining of human small intestine
Figure 3 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70524/162441_A_4_2_selected.jpg
Figure 4 IHC staining of human kidney
Figure 4 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in renal tubular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_8_5_selected.jpg
Figure 5 IF staining of human cell line A-431
Figure 5 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/659_B11_4_blue_red_green.jpg
Figure 6 IF staining of human cell line U-251 MG
Figure 6 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/658_B11_1_blue_red_green.jpg
Normal Tissue
Figure 7 Cerebral cortex
Figure 7 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_7_5.jpg
Figure 8 Colon
Figure 8 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_9_3.jpg
Figure 9 Liver
Figure 9 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_8_4.jpg
Figure 10 Kidney
Figure 10 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_5.jpg
Figure 11 Testis
Figure 11 Testis
(Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_4_6.jpg
Figure 12 Skin
Figure 12 Skin
(Fibroblasts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Langerhans
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Melanocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_8_1.jpg
Figure 13 Lymph node
Figure 13 Lymph node
(Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_8.jpg
RNA Expression
Figure 14 RNA cell line category: Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)
Figure 14 RNA cell line category: Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000065361-ERBB3

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human and Rat ERBB3
  • Species Reactivity
  • Human, Rat
  • Clone
  • R04-8J6
  • Applications
  • WB, IP
  • Related Disease
  • Lethal Congenital Contracture Syndrome 2

Product Property

  • Clonality
  • Monoclonal
  • Aggregation
  • < 5%
  • Format
  • Liquid
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • WB: 1/500-1/1000
    IP: 1/20

Target

  • Alternative Names
  • HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3
  • Long Name
  • erb-b2 receptor tyrosine kinase 3
  • Cellular Localization
  • Cell membrane
  • Post Translation Modifications
  • Glycosylation at Asn126, Asn250, Asn353, Asn408, Asn414, Asn437, Asn469, Asn522, Asn566, and Asn616 (NX_P21860 [NX_P21860-1])
    Modification sites at PhosphoSitePlus (P21860)
    Glycosylation from GlyConnect ERBB3_HUMAN (1711)
    Glycosylation from GlyGen (P21860) 10 sites, 5 N-linked glycans (3 sites)
  • Function
  • Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins.
    Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
    May also be activated by CSPG5 (PubMed:15358134).
    Involved in the regulation of myeloid cell differentiation.

Recommended Products

Isotype Control

Recommended Dilution Buffer

Secondary Antibody

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ERBB3"

Select a product category from the dropdown menu below to view related products.
Please select product type
Single Domain Antibody Products Humanized Antibody Products Immunotoxin Products IgG Antibody Products Human Antibody Products Mouse Antibody Products Chimeric Antibody Products Neutralizing Antibody Products Rabbit Monoclonal Antibody Products Fab Antibody Products ScFv Antibody Products ADCC Enhanced Antibody Products Antibody Magnetic Beads ScFv-Fc Chimera Products
CAT Product Name Application Type
NAB-1729-sdAb Recombinant Anti-human ERBB3 VHH Single Domain Antibody WB, ICC, ChiP, FA, ELISA Llama VHH
TAB-070CT Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) FC, Block Llama VHH
PABC-556 Recombinant Llama Anti-ERBB3 Single Domain Antibody (PABC-556) ELISA, SPR Llama VHH

Customer Reviews and Q&As

Submit a review or a question

There are currently no Customer reviews or questions for VS3-XY3348. Click the button above to contact us or submit your feedback about this product.

Popular products with customers

Figure 1 Anti-Human NRP1 Therapeutic Antibody (TAB-264) in DB

Anti-Human NRP1 Recombinant Antibody (Vesencumab) (CAT# TAB-264)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Figure 1 Anti-Human Integrin alpha 5 beta 1 Recombinant Antibody in SDS-PAGE analysis.

Anti-Human Integrin alpha 5 beta 1 Recombinant Antibody (Volociximab) (CAT# TAB-077)
Application: ELISA, IHC

Anti-C. difficile toxin B Therapeutic Antibody (bezlotoxumab) (TAB-725) in ELISA

Anti-C. Diff Toxin B Recombinant Antibody (Bezlotoxumab) (CAT# TAB-725)
Application: WB, FC, IP, ELISA, Neut, FuncS, IF

Figure 1 IGF1R Recombinant Antibody (TAB-736) in SDS-PAGE

Anti-IGF1R Recombinant Antibody (TAB-736) (CAT# TAB-736)
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC

Figure 1 Anti-CD70 Antibody (GLY-008CL) in ELISA

Anti-CD70 monoclonal antibody (MDX-1411) (CAT# Gly-008CL)
Application:

Figure 1 Anti-Human CD5 Recombinant Antibody (TAB-308LC) in SDS-PAGE

Anti-Human CD5 Recombinant Antibody (5D7) (CAT# TAB-308LC)
Application: Cyt, FC, FuncS

Figure 1 Anti-FGFR1 Therapeutic Antibody (FR1-H7) (TAB-052WM) in Western Blot

Anti-Human FGFR1 Recombinant Antibody (FR1-H7) (CAT# TAB-052WM)
Application: ELISA, Neut

Figure 1 Anti-Human RNF43 Recombinant Antibody (TAB-328CT) in SDS-PAGE

Humanized Anti-RNF43 Recombinant Antibody (TAB-328CT) (CAT# TAB-328CT)
Application: WB, ELISA, FC, IHC, IP

Figure 1 Anti-Human RNF43 Recombinant Antibody scFv Fragment (TAB-328CT-S(P)) in SDS-PAGE

Humanized Anti-RNF43 Recombinant Antibody; scFv Fragment (TAB-328CT-S(P)) (CAT# TAB-328CT-S(P))
Application: WB, ELISA, FC, IHC, IP

Figure 1 Anti-Influenza A Virus (H1N1/H2N2) HA Recombinant Antibody (MRO-248LC) in SDS-PAGE

Anti-Influenza A Virus (H1N1/H2N2) HA Recombinant Antibody (C179) (CAT# MRO-248LC)
Application: ELISA

Figure 1 Anti-Human F8 Antibody in SDS-PAGE

Recombinant Human Anti-F8 Antibody (BO2C11) (CAT# PABX-058)
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR

Figure 1 Anti-CD5 Antibody (53-7.3) Fab Fragment (NEUT-392CQ-Fab) in WB

Rat Anti-CD5 Recombinant Antibody (clone 53-7.3) (CAT# NEUT-392CQ)
Application: FC, IHC-Fr, IP, ELISA, Block

Figure 1 Anti-Human IL23A Therapeutic Antibody (Brazikumab) (TAB-008ML) in SDS-PAGE

Anti-Human IL23A Recombinant Antibody (Brazikumab) (CAT# TAB-008ML)
Application: ELISA, IHC, FC, IP, IF, Inhib

Figure 1 Mouse Anti-SOST Recombinant Antibody (HPAB-0343-YC) in SDS-PAGE

Mouse Anti-SOST Recombinant Antibody (HPAB-0343-YC) (CAT# HPAB-0343-YC)
Application: FuncS

Figure 1 Human IgG2, kappa Isotype Control Antibody (MOB-197CQ) in SDS-PAGE

Human IgG2, kappa Isotype Control Antibody (CAT# MOB-197CQ)
Application: FC, ELISA

Figure 1 Anti-Human IAV HA Recombinant Antibody (MOB-074LC) in SDS-PAGE

Human Anti-EPCAM Recombinant Antibody (clone ING-1) (CAT# MOB-074LC)
Application: ELISA, FuncS

Figure 1 Mouse Anti-Histone Recombinant Antibody (clone BWA3) (FAMAB-0162YC) in SDS-PAGE

Mouse Anti-Histone Recombinant Antibody (clone BWA3) (CAT# FAMAB-0162YC)
Application: IF

Figure 1 Recombinant Human Anti-EBV gH/gL Antibody (AMMO1) (PABC-311) in SDS-PAGE

Recombinant Human Anti-EBV gH/gL Antibody (AMMO1) (CAT# PABC-311)
Application: ELISA, BLI, Neut

Figure 1 Recombinant Human Anti-HA Antibody (HPAB-M0100-YC) in SDS-PAGE

Human Anti-HA Recombinant Antibody (HPAB-M0100-YC) (CAT# HPAB-M0100-YC)
Application: ELISA, FuncS

Figure 1 Mouse Anti-SOX9 Antibody (clone ABT-SOX9) in IHC

Mouse Anti-SOX9 Recombinant Antibody (clone ABT-SOX9) (CAT# ZG-0104C)
Application: IHC-P, IF

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare