Rabbit Anti-PRNP Recombinant Antibody (clone R03-2E2) (CAT#: VS3-FY1851)
The R03-2E2 recombinant monoclonal antibody exhibits specific binding to human PRNP. It cross-reacts with mouse, rat. It is suitable for use in a variety of assays, including WB, IHC-P. The binding specificity of the Prion protein antibody was determined using western blot analysis of Prion Protein in U251 lysates.
Specific Inquiry
WB
Figure 1 Anti-PRNP Antibody (VS3-FY1851) in WB.
The Prion Protein expression in U251 lysates were detected using the anti-Prion Protein by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human prion protein PrP
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat PRNP
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-2E2
- Applications
- Western Blot, Immunohistochemistry-Paraffin
- MW
- The calculated weight of the target protein is approximately 28 kDa, while the observed molecular weight stands at 28 kDa.
- Related Disease
- Prion diseases
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- CJD, GSS, PrP, ASCR, KURU, PRIP, PrPc, CD230, AltPrP, p27-30, PrP27-30, PrP33-35C
- Gene ID
- 5621
- UniProt ID
- P04156
- Sequence Similarities
- Belongs to the prion family.
- Cellular Localization
- Amyloid, Cell membrane, Golgi apparatus, Membrane
- Post Translation Modifications
- The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion. (P04156-PRIO_HUMAN)
Glycosylation at Thr95, Asn181, Thr193, and Asn197 (NX_P04156 [NX_P04156-1])
Modification sites at PhosphoSitePlus (P04156)
Glycosylation from GlyConnect PRIO_HUMAN (2056)
Glycosylation from GlyGen (P04156) 4 sites, 6 N-linked glycans (1 site), 2 O-linked glycans (2 sites)
- Protein Refseq
- NP_000302.1; NP_001073590.1; NP_001073591.1; NP_001073592.1; NP_001258490.1
- Function
- May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Intrabody Products
IgG Antibody Products
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IgM Antibody Products
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Human Antibody Products
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Rabbit Monoclonal Antibody Products
Epitope-Specific Antibody Products
Fab Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B034(A) | Recombinant Anti-human PRNP Intrabody [(D-Arg)9] | IF, FC, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B034(G) | Recombinant Anti-human PRNP Intrabody [+36 GFP] | WB, CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B034(T) | Recombinant Anti-human PRNP Intrabody [Tat] | IF, ELISA, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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