Recombinant Rabbit Anti-IL17A Capture Antibody (clone R05-7K8)
CAT#: VS3-WK1720
This antibody is a rabbit recombinant antibody against human IL17A. It was developed by immunization of rabbit with recombinant human IL17A protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R05-7K8 and R04-4G2. The clone R05-7K8 can be used as a capture antibody in ELISA analysis to identify human IL17A.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
Normal Tissue
Figure 7 Tonsil
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A
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Specifications
- Immunogen
- Recombinant human IL17A protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IL17A
- Species Reactivity
- Human
- Clone
- R05-7K8
- Applications
- ELISA
- Conjugate
- Unconjugated
- Related Disease
- Autoimmune diseases; Tumors
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 17A
- Gene ID
- 3605
- UniProt ID
- Q16552
- Long Name
- Interleukin 17A
- Sequence Similarities
- Belongs to the IL-17 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- N-glycosylated. Found both in glycosylated and nonglycosylated forms.
- Protein Refseq
- NP_002181.1
- Function
- Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity.
Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Detection antibody
Isotype Control
- CAT
- Product Name
Secondary Antibody
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|---|---|---|---|
| TAB-069 | Anti-Human IL17A Recombinant Antibody (TAB-069) | IF, IHC, ELISA, FC | IgG1 - kappa |
| TAB-078ZJ | Human Anti-IL17A Recombinant Antibody (TAB-078ZJ) | ELISA, Block, Neut | Human antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H57 | Anti-Human IL17A Recombinant Antibody (Perakizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
| TAB-H08 | Anti-Human IL17A/IL17F Recombinant Antibody (TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-048ZJ | Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) | ELISA, Neut | Humanized antibody |
| TAB-048ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-048ZJ-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-458CQ | Anti-Human IL17A Recombinant Antibody (TAB-458CQ) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-399CL | Human Anti-IL17A Recombinant Antibody (TAB-399CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
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| PABL-237 | Human Anti-IL17A Recombinant Antibody (clone CNTO7357) | WB, IHC, FuncS | Human IgG |
| PABL-238 | Human Anti-IL17A Recombinant Antibody (clone Fab6785) | WB, ELISA, FuncS | Human IgG |
| HPAB-0207-LSX | Human Anti-IL17A Recombinant Antibody (HPAB-0207-LSX) | ELISA | Human IgG |
| HPAB-0208-LSX | Human Anti-IL17A Recombinant Antibody (HPAB-0208-LSX) | ELISA, FuncS | Human IgG |
| HPAB-0209-LSX | Human Anti-IL17A Recombinant Antibody (HPAB-0209-LSX) | ELISA | Chimeric IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-237 | Human Anti-IL17A Recombinant Antibody (clone CNTO7357); Fab Fragment | WB, IHC, FuncS | Human Fab |
| PFBL-238 | Human Anti-IL17A Recombinant Antibody (clone Fab6785); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0207-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0207-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0208-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0208-LSX-F(E)) | ELISA | Human Fab |
| HPAB-0209-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0209-LSX-F(E)) | ELISA | Chimeric Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030ZJ | Mouse Anti-IL17A Recombinant Antibody (TAB-030ZJ) | ELISA, Neut | Mouse IgG |
| TAB-030ZJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-030ZJ-S(P)) | ELISA, Neut | Mouse scFv |
| TAB-030ZJ-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-030ZJ-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-077LC | Recombinant Anti-Human IL17A Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0289MZ | Chicken Anti-Interleukin-17a Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1202CQ | Mouse Anti-IL17A Recombinant Antibody (NEUT-1202CQ) | Neut | Mouse IgG2a |
| NEUT-1203CQ | Mouse Anti-IL17A Recombinant Antibody (NEUT-1203CQ) | Neut | Mouse IgG1 |
| NEUT-1204CQ | Mouse Anti-IL17A Recombinant Antibody (clone 403D10.01) | Neut, FC | Mouse IgG1 |
| NEUT-1205CQ | Mouse Anti-IL17A Recombinant Antibody (clone 408H6.01) | Neut, ELISA, FC | Mouse IgG2a |
| NEUT-1206CQ | Mouse Anti-IL17A Recombinant Antibody (clone 409H7.05) | Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-042CN | Mouse Anti-IL17A Recombinant Antibody (NS-042CN) | ELISA, FC | Mouse IgG |
| NS-042CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (NS-042CN-F(E)) | ELISA, FC | Mouse Fab |
| NS-042CN-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (NS-042CN-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-WJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone CJM112); scFv Fragment | ELISA | Human scFv |
| HPAB-0059-WJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0059-WJ-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-0850-FY-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0850-FY-F(E)) | Neut | Humanized Fab |
| HPAB-0851-FY-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0851-FY-F(E)) | ELISA | Human Fab |
| HPAB-0852-FY-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0852-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-458CQ | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-458CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-069 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-069) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H08 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-H57 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H57) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
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