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    Recombinant Rabbit Anti-IL17A Capture Antibody (clone R05-7K8) (CAT#: VS3-WK1720)

    This antibody is a rabbit recombinant antibody against human IL17A. It was developed by immunization of rabbit with recombinant human IL17A protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R05-7K8 and R04-4G2. The clone R05-7K8 can be used as a capture antibody in ELISA analysis to identify human IL17A.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human small intestine
    Figure 1 IHC staining of human small intestine
    (Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
    Figure 7 Tonsil
    Figure 7 Tonsil
    (Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)
    Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A

    Specifications

    • Immunogen
    • Recombinant human IL17A protein
    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human IL17A
    • Species Reactivity
    • Human
    • Clone
    • R05-7K8
    • Applications
    • ELISA
    • Conjugate
    • Unconjugated
    • Related Disease
    • Autoimmune diseases; Tumors

    Product Property

    • Clonality
    • Monoclonal
    • Purification
    • Protein A affinity purified
    • Purity
    • >95% as determined by SDS-PAGE
    • Aggregation
    • < 5%
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • 0.01M PBS, pH 7.2
    • Storage
    • Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
    • Shipping
    • Ice packs

    Target

    • Alternative Names
    • Interleukin 17A
    • Long Name
    • Interleukin 17A
    • Sequence Similarities
    • Belongs to the IL-17 family.
    • Cellular Localization
    • Secreted
    • Post Translation Modifications
    • N-glycosylated. Found both in glycosylated and nonglycosylated forms.
    • Function
    • Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity.
      Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.

    Recommended Products

    Detection antibody

    Isotype Control

    Secondary Antibody

    Related Resources

    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "IL17A"

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    CAT Product Name Application Type
    TAB-069 Anti-Human IL17A Recombinant Antibody (TAB-069) IF, IHC, ELISA, FC IgG1 - kappa
    TAB-078ZJ Human Anti-IL17A Recombinant Antibody (TAB-078ZJ) ELISA, Block, Neut Human antibody
    TAB-079ZJ Human Anti-IL17A Recombinant Antibody (TAB-079ZJ) ELISA, Block, Neut Human IgG1
    TAB-080ZJ Human Anti-IL17A Recombinant Antibody (TAB-080ZJ) ELISA, Block, Neut Human antibody
    PABX-116 Recombinant Human Anti-Il-17A Antibody (CAT-2200) WB, ELISA, FuncS IgG

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