Recombinant Rabbit Anti-IL17A Capture Antibody (clone R05-7K8) (CAT#: VS3-WK1720)
This antibody is a rabbit recombinant antibody against human IL17A. It was developed by immunization of rabbit with recombinant human IL17A protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R05-7K8 and R04-4G2. The clone R05-7K8 can be used as a capture antibody in ELISA analysis to identify human IL17A.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
(Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
Figure 7 Tonsil
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A
Specifications
- Immunogen
- Recombinant human IL17A protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IL17A
- Species Reactivity
- Human
- Clone
- R05-7K8
- Applications
- ELISA
- Conjugate
- Unconjugated
- Related Disease
- Autoimmune diseases; Tumors
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 17A
- Gene ID
- 3605
- UniProt ID
- Q16552
- Long Name
- Interleukin 17A
- Sequence Similarities
- Belongs to the IL-17 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- N-glycosylated. Found both in glycosylated and nonglycosylated forms.
- Protein Refseq
- NP_002181.1
- Function
- Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity.
Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
Recommended Products
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Related Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H57 | Anti-Human IL17A Recombinant Antibody (Perakizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
| TAB-H08 | Anti-Human IL17A/IL17F Recombinant Antibody (TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-048ZJ | Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) | ELISA, Neut | Humanized antibody |
| TAB-048ZJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P)) | ELISA, Neut | Human scFv |
| TAB-048ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-048ZJ-F(E)) | ELISA, Neut | Humanized Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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