Recombinant Rabbit Anti-IL1B Capture Antibody (clone R02-6W6)

Name: Recombinant Rabbit Anti-IL1B Capture Antibody (clone R02-6W6)
SKU: VS3-WK1758
Rating: 5 (1 reviews)

CAT#: VS3-WK1758

This antibody is a rabbit recombinant antibody against mouse IL1B. It was developed by immunization of rabbit with recombinant mouse IL1B protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R02-6W6 and R05-7Z7. The clone R02-6W6 can be used as a capture antibody in ELISA analysis to identify mouse IL1B.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced.

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125538-IL1B

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Specifications

Immunogen
Recombinant mouse IL1B protein

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Mouse IL1B

Species Reactivity
Mouse

Clone
R02-6W6

Applications
ELISA

Conjugate
Unconjugated

Product Property

Clonality
Monoclonal

Purification
Protein A affinity purified

Purity
>95% as determined by SDS-PAGE

Aggregation
< 5%

Format
Liquid

Concentration
Please refer to the vial label for the specific concentration.

Buffer
0.01M PBS, pH 7.2

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping
Ice packs

Target

Alternative Names
Il-1b; IL-1beta

Gene ID
16176

UniProt ID
P10749

Long Name
Interleukin 1 beta

Sequence Similarities
Belongs to the IL-1 family.

Cellular Localization
Cytoplasm, Lysosome, Secreted

Protein Refseq
NP_032387.1

Function
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.

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Related Diseases

Rheumatoid Arthritis

Maturity Onset Diabetes of the Young

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS3-WK1758.pdf

MSDS

MSDS - VS3-WK1758.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Detection antibody

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Secondary Antibody

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