Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
+ Filter
Loading...
Custom Services order now ship next day

APC

Recombinant Antibody Products Formats

Anti-APC Recombinant Antibody Products

More Infomation

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.


This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Astrocytes, Inhibitory neurons, Bipolar cells, Oligodendrocyte precursor cells, Excitatory neurons)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Forms homooligomers and heterooligomers with APC2. Interacts with DIAPH1 and DIAPH2 (By similarity). Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with ARHGEF4 (via N-terminus). Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with SCRIB; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts at the cell membrane with AMER1 and AMER2 (via ARM repeats). Interacts with KHDRBS1. The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (PubMed:25169422).

More Types Infomation
Related Diseases
Breast Cancer Breast Cancer
Colorectal Cancer Colorectal Cancer
Endometrial Cancer Endometrial Cancer
Gastric Cancer Gastric Cancer
Pancreatic Cancer Pancreatic Cancer
Prostate Cancer Prostate Cancer
Throid Cancer Throid Cancer
Hepatocellular Carcinoma Hepatocellular Carcinoma
Cushing Syndrome Cushing Syndrome
Related Signaling Pathways
Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway Non-Canonical Wnt Signaling Pathway
  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare