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The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, FuncS
Species Reactivity:
Human
Type:
Mouse antibody
Application:
IHC-P
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, IF, FuncS
Species Reactivity:
human
Type:
vhh-(D-Arg)9
Application:
ELISA, ICC, FuncS
Species Reactivity:
human
Type:
vhh-(+36GFP)
Application:
PCA, Neut, FuncS
Species Reactivity:
human
Type:
vhh-Tat
Application:
WB, Neut, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, FuncS
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
IHC-P
Species Reactivity:
Human
Type:
Single Domain Antibody
Derivation:
Naive VHH phage display library
Type:
Single domain antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Naive VHH phage display library
Type:
Single domain antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Naive VHH phage display library
Type:
Single domain antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Naive VHH phage display library
Type:
Single domain antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Naive VHH phage display library
Type:
Single domain antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Naive VHH phage display library
Type:
Single domain antibody
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IF, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, WB, FC, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, Neut, FuncS
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