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    CD28 & FOLR1

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    Anti-CD28 & FOLR1 Products

    • Anti-FR-S-S-Dox ADC (ADC-170LZY)
      • Target: folate receptor (FR)
      • Linker: disulfide ("S-S") linker
      • Drug: doxorubicin
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    • Anti-FRα-DGN462 ADC (ADC-120LZY)
      • Target: FRα
      • Linker: maleimide containing linkers
      • Drug: DGN462
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    • Anti-FRα (clone M9346A)-SPDB-DM4 ADC (ADC-073LZY)
      • Target: FRα
      • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
      • Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular).
    CD28 & FOLR1
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