CD28 & FOLR1
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized V-kappa
- Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, Stim
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Human IgG1, κ
- Application: ELISA, WB, IHC
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- Derivation: Mouse
- Species Reactivity: canine
- Type: Mouse IgG1
- Application: WB, ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS, Activ
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- Species Reactivity: Human
- Application: FC, ICC/IF, IHC-Fr, IP, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: FC, FuncS, Neut, WB
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- Species Reactivity: Mouse
- Type: Mouse IgG2b, κ
- Application: FC, Costim, Block
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- Species Reactivity: Mouse
- Type: Hamster IgG
- Application: IHC-Fr, FC, IP, Block, FuncS
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- Species Reactivity: Mouse
- Type: Hamster IgG1
- Application: Neut
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, FC, IHC
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- Species Reactivity: Mouse
- Type: Hamster IgG
- Application: ELISA, FC, Neut
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1
- Application: ELISA, FC, IHC
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- Species Reactivity: Human, Cynomolgus
- Type: Human scFv
- Application: ELISA, WB, IHC
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Humanized Fab
- Application: ELISA, WB, IHC
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Human scFv
- Application: ELISA, WB, IHC
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Human antibody
- Application: IHC
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Human antibody
- Application: IHC
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, WB
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, WB
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- Derivation: Chimeric (Rat/Human)
- Species Reactivity: Human, Cynomolgus
- Type: Chimeric (Rat/Human) Fab
- Application: ELISA, WB, IHC
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Human antibody
- Application: IHC
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- Species Reactivity: Human, Non-Human Primates
- Type: Mouse IgG1
- Application: FC, IP, WB, IHC, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG, κ
- Application: ELISA
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, WB
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: FC, ELISA
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: FC, ELISA
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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- Derivation: Chimeric (Rat/Human)
- Species Reactivity: Human, Cynomolgus
- Type: Chimeric (Rat/Human) IgG1, κ
- Application: ELISA, WB, IHC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: FC, IF, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IHC, WB, IP
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, IHC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Chicken, Turkey
- Type: Mouse IgG
- Application: FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC, IHC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Chicken, Turkey
- Type: Mouse Fab
- Application: FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Chicken, Turkey
- Type: Mouse scFv
- Application: FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, IHC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized VH
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized VH
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC, IHC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC, IHC
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- Species Reactivity: Human, Cynomolgus
- Type: Rat IgG1, κ
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG1 F(ab')2, κ
- Application: Agonist, Stim, Neu, FC
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- Target: α-FR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Chimeric (Human-Mouse)
- Cytokine 1 Species: Human
- Molecule Class: IL2-scFv
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- Target: CD28
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IL2-IgG2a
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- Derivation: Mouse
- Species Reactivity: canine
- Type: Mouse Fab
- Application: WB, ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse scFv
- Application: WB, ELISA, FuncS
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- Target: CD28
- Species Reactivity: Human
- Cytokine 1: TNF
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: TNF-IgG2a
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- Species Reactivity: Human, Cynomolgus
- Type: Rat scFv
- Application: ELISA, WB, IHC
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- Species Reactivity: Human, Cynomolgus
- Type: Rat Fab
- Application: ELISA, WB, IHC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB, IHC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB, IHC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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- Targets: CD28 & FOLR1
- Type: Fab2
- Application: FuncS, Promising therapeutic agent
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Asn299 of heavy chain
- Glycoform (ratio): M3N2F
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Asn299 of heavy chain
- Glycoform (ratio): NGA2
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Asn299 of heavy chain
- Glycoform (ratio): NGA2
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- Target: FOLR1
- Linker: sulfo-SPDB (sulfosuccinimidyl N-succinimidyl-4-(2-pyridyldithio)butyrate)
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
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- Target: folate receptor (FR)
- Linker: disulfide ("S-S") linker
- Drug: doxorubicin
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- Species Reactivity: human
- Type: scFv-Tat
- Application: WB, ICC, Neut, FuncS
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- Target: FRα
- Linker: maleimide containing linkers
- Drug: DGN462
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- Target: FRα
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Species Reactivity: human
- Type: scFv-(+36GFP)
- Application: WB, Neut, FuncS
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- Target: FOLR1
- Linker: sulfo-SPDB
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Species Reactivity: human
- Type: scFv-(D-Arg)9
- Application: PCA, Neut, FuncS
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