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EGFR
Engineered Antibody Products
Antibody-like Scaffold Protein Products
Glyco-Engineering Antibody Products
Tetramer Products
Antibody Magnetic Beads
Cancer Stem Cell Biomarker Specific Antibody Products
AbPlus
Recombinant Antibody Products
Functional Antibody Products
Formats
Research Area
Anti-EGFR Recombinant Antibody Products
- Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
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- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
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- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-EGFR-mc-MMAF ADC (ADC-039CL)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-EGFR (clone Antibody 1)-MC-MMAF ADC (ADC-059CL)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-EGFR (clone Bat0206)-S-3AA-MDC ADC (ADC-157CL)
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- Target: EGFR
- Linker: S-3AA
- Drug: MDC (maytansinol)
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- Anti-EGFR (clone Bat0206)-SMCC-MDC ADC (ADC-158CL)
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- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: MDC (maytansinol)
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- Host Species: Human
- Specificity: Human
- Type: Humanized antibody
- Glycosylation site: Asn297 in Fc region
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- Anti-EGFR-doxorubicin ADC (ADC-168LZY)
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- Target: EGFR
- Linker: polyethylene glycol linker
- Drug: doxorubicin
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- Anti-EGFR (ABT-806)-Mc-MMAE ADC (ABT-414) (ADC-L001)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
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- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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- Cetuximab (Gly-015CL)
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- CAS number: 205923-56-4
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- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Glycosylation site: Asn297 in Fc region
- Glycoform (ratio): Man3GlcNAc2
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- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Glycosylation site: Asn297 in Fc region
- Glycoform (ratio): Man3GlcNAc2
Compare
- Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
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- Target: EGFR
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: doxorubicin
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- Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
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- Target: EGFR
- Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
- Drug: doxorubicin
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- Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
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- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: MTX
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- Anti-EGFR-EDC/NHS-methotrexate ADC (ADC-060LZY)
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- Target: EGFR
- Linker: EDC/NHS
- Drug: MTX
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- Anti-EGFR (clone ABT-806)-mc-MMAF ADC (ADC-071LZY)
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- Target: EGFR
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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- Anti-EGFR-vc-Duostatin-3 ADC (ADC-088LZY)
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- Target: EGFR
- Linker: VC (valine-citrulline)
- Drug: Duostatin-3
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- Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
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- Target: epidermal growth factor receptor (EGFR)
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MODO (monomethyldolastatin)
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- Anti-EGFR-Mal-dPEG4-NHS-DM1 ADC (ADC-107LCT)
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- Target: EGFR
- Linker: Mal-dPEG4-NHS
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Anti-EGFR (MAb806)-Mc-MMAF ADC (ADC-109LCT)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
Compare
- Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
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- Target: EGFR variant III
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Compare
- Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
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- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Compare
- Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
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- Target: EGFRvIII
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
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Related Signaling Pathways
JAK-STAT Signaling Pathway
