EGFR

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Anti-EGFR Recombinant Antibody Products

Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-EGFR-mc-MMAF ADC (ADC-039CL)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (clone Antibody 1)-MC-MMAF ADC (ADC-059CL)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (clone Bat0206)-S-3AA-MDC ADC (ADC-157CL)
- Target: EGFR
- Linker: S-3AA
- Drug: MDC (maytansinol)
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Anti-EGFR (clone Bat0206)-SMCC-MDC ADC (ADC-158CL)
- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: MDC (maytansinol)
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Recombinant Anti-Human EGFR Antibody (Fc glycosylation) (Gly-144LC)
- Host Species: Human
- Specificity: Human
- Type: Humanized antibody
- Glycosylation site: Asn297 in Fc region
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Recombinant Anti-Human EGFR Antibody (Non-glycosylated) (Gly-167LC)
- Host Species: Human
- Specificity: Human
- Type: Human antibody
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Anti-EGFR-doxorubicin ADC (ADC-168LZY)
- Target: EGFR
- Linker: polyethylene glycol linker
- Drug: doxorubicin
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Anti-EGFR (ABT-806)-Mc-MMAE ADC (ABT-414) (ADC-L001)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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Cetuximab (Gly-015CL)
- CAS number: 205923-56-4
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Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) (Gly-055LC)
- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Glycosylation site: Asn297 in Fc region
- Glycoform (ratio): Man3GlcNAc2
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Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) (Gly-055LC-1)
- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Glycosylation site: Asn297 in Fc region
- Glycoform (ratio): Man3GlcNAc2
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Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
- Target: EGFR
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: doxorubicin
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Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
- Target: EGFR
- Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
- Drug: doxorubicin
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Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: MTX
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Anti-EGFR-EDC/NHS-methotrexate ADC (ADC-060LZY)
- Target: EGFR
- Linker: EDC/NHS
- Drug: MTX
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Anti-EGFR (clone ABT-806)-mc-MMAF ADC (ADC-071LZY)
- Target: EGFR
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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Anti-EGFR-vc-Duostatin-3 ADC (ADC-088LZY)
- Target: EGFR
- Linker: VC (valine-citrulline)
- Drug: Duostatin-3
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Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
- Target: epidermal growth factor receptor (EGFR)
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MODO (monomethyldolastatin)
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Anti-EGFR-Mal-dPEG4-NHS-DM1 ADC (ADC-107LCT)
- Target: EGFR
- Linker: Mal-dPEG4-NHS
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-EGFR (MAb806)-Mc-MMAF ADC (ADC-109LCT)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
- Target: EGFR variant III
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
- Target: EGFRvIII
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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For Research Use Only. Not For Clinical Use.

EGFR encodes a receptor tyrosine kinase that is involved in the regulation of cell growth, survival, and differentiation. It is activated by binding to its ligands, such as epidermal growth factor (EGF), and mediates downstream signaling pathways that control cellular processes like proliferation, migration, and differentiation. EGFR is critical in normal development, wound healing, and tissue repair. However, mutations or overexpression of EGFR are associated with various cancers, including non-small cell lung cancer (NSCLC), making EGFR a target for cancer therapies, including monoclonal antibodies and tyrosine kinase inhibitors.