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EGFR

Engineered Antibody Antibody-like Scaffold Protein Glyco-Abs MHC Antibody Magnetic Beads
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
EGFR
Related Diseases
Bladder Cancer Bladder Cancer
Non-small Cell Lung Cancer Non-small Cell Lung Cancer
Pancreatic Cancer Pancreatic Cancer
Hepatocellular Carcinoma Hepatocellular Carcinoma
Cushing Syndrome Cushing Syndrome
Related Signaling Pathways
JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
  • Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: MTX
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  • Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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  • Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
    • Target: EGFR
    • Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
    • Drug: doxorubicin
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  • Anti-EGFR-mc-MMAF ADC (ADC-039CL)
    • Target: EGFR
    • Linker: Mc (maleimidocaproyl)
    • Drug: MMAF (Monomethyl auristatin F)
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  • Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
    • Target: EGFR variant III
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
    • Target: EGFR
    • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: doxorubicin
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  • Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
    • Target: EGFRvIII
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
    • Target: EGFR
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
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  • Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
    • Target: epidermal growth factor receptor (EGFR)
    • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MODO (monomethyldolastatin)
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  • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
    • Target: EGFR
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
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