MUC1 & CD28

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Anti-MUC1 & CD28 Recombinant Antibody Products

Anti-mucin (clone hPAM4)-SN-38 ADC (ADC-121CL)
- Target: mucin
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
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Anti-CanAg (huC242)-Mal-dPEG4-NHS-DM1 ADC (ADC-008LCT)
- Target: CanAg
- Linker: PEG4Mal
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CanAg (huC242)-SMCC-DM1 ADC (ADC-009LCT)
- Target: CanAg
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CanAg (huC242)-Sulfo-SPDB-DM4 ADC (ADC-010LCT)
- Target: CanAg
- Linker: sulfo-SPDB (sulfo-N-succinimidyl 4-(2-pyridyldithio)butyrate
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Anti-CanAg (huC242)-SPDB-DM4 ADC (ADC-011LCT)
- Target: CanAg
- Linker: SPDB
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Anti-CanAg (huC242)-SPP-DM1 ADC (ADC-012LCT)
- Target: CanAg
- Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) (Gly-124LC)
- Host Species: Mouse
- Specificity: Human
- Type: Mouse antibody
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Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) (Gly-012LC)
- Host Species: Human
- Specificity: Human
- Type: Humanized antibody
- Glycosylation site: CDR2 of VH
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Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) (Gly-012LC-1)
- Host Species: Human
- Specificity: Human
- Type: Humanized antibody
- Glycosylation site: CDR2 of VH
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Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) (Gly-109LC)
- Host Species: Human
- Specificity: Human
- Type: Human antibody
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Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) (Gly-120LC)
- Host Species: Mouse
- Specificity: Human
- Type: Mouse antibody
- Glycosylation site: Asn56 in VH
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Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) (Gly-121LC)
- Host Species: Mouse
- Specificity: Human
- Type: Mouse antibody
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Recombinant Anti-Human MUC1 Antibody (Non-glycosylated) (Gly-122LC)
- Host Species: Mouse
- Specificity: Human
- Type: Mouse antibody
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Anti-CanAg (clone huC242)-SPP-DM1 ADC (ADC-209LZY)
- Target: CanAg
- Linker: SPP(N-succinimidyl 4-(2-pyridyldithio)pentanoate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-CanAg (clone huC242)-SPP-[3H]DM1 ADC (ADC-212LZY)
- Target: CanAg
- Linker: SPP(N-succinimidyl 4-(2-pyridyldithio)pentanoate)
- Drug: [3H]DM1([3H]N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-CanAg (clone huC242)-SMCC-[3H]DM1 ADC (ADC-213LZY)
- Target: CanAg
- Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
- Drug: [3H]DM1([3H]N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-CanAg (clone huC242)-SPDB-[3H]DM4 ADC (ADC-214LZY)
- Target: CanAg
- Linker: SPDB(N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: [3H]DM4([3H]N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Anti-mucin repeats (clone ch3A5)-mc-MMAF ADC (ADC-219LZY)
- Target: mucin repeats
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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Anti-mucin repeats (clone ch3A5)-vc-MMAF ADC (ADC-220LZY)
- Target: mucin repeats
- Linker: VC (valine-citrulline)
- Drug: MMAF (monomethyl auristatin F)
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Anti-CAIX-mcc-MMAE ADC (ADC-013LCT)
- Target: CAIX, Carbonic anhydrase IX
- Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CA6 (clone huDS6)-SPDB-DM4 ADC (ADC-012LZY)
- Target: CA6, a specific glycol-epitope of MUC-1
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Anti-CanAg (clone huC242)-SPDB-DM4 ADC (ADC-092LZY)
- Target: CanAg
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Anti-CanAg (clone huC242)-SMCC-DM1 ADC (ADC-102LZY)
- Target: CanAg
- Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-Mucin1-DM4 ADC (ADC-112LZY)
- Target: Mucin1
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Anti-MUC1 (clone hPAM4)-CL2A-SN-38 ADC (ADC-162LZY)
- Target: MUC1
- Linker: CL2A
- Drug: SN-38(7-ethyl-10-hydroxy camptothecin)
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Recombinant Anti-MUC1 × Anti-CD28 Bispecific Antibody (Fab₂) (FAB-L072)
- Targets: MUC1 & CD28
- Type: Fab₂
- Application: FuncS, Promising therapeutic agent
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For Research Use Only. Not For Clinical Use.

MUC1 encodes a cell surface glycoprotein that functions as a protective mucin, contributing to the barrier function of epithelial tissues. It is involved in protecting the gastrointestinal, respiratory, and genitourinary tracts from pathogens. MUC1 is also implicated in cancer progression, particularly in breast, lung, and pancreatic cancers, where it can be overexpressed, influencing cell signaling and tumor growth.

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.