Anti-human IL2RA scFv Fragment (Inolimomab) (CAT#: TAB-641LC-S(P))

Recombinant monoclonal antibody Inolimomab is a mouse monoclonal antibody that specifically binds to human IL-2Rα and can be potentially used in the treatment of graft versus host disease.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Kaplan–Meier OS (left) and TRM (right) curves of corticosteroid refractory aGVHD patients treated with Inolimomab from the time of HSCT.

Figure 1 Kaplan–Meier OS (left) and TRM (right) curves of corticosteroid refractory aGVHD patients treated with Inolimomab from the time of HSCT.

At 3 years: OS=54.5% (95% CI=36.3–69.6%) and TRM=29.7% (95% CI=16.6–49.6%).

Girerd, S., Renaud, M., Guilhot, J., Giraud, C., Larchee, R., Jollet, I., & Guilhot, F. (2013). Long-term follow-up of corticosteroid refractory acute GVHD treated with an Inolimomab-based algorithm: a single center experience. Bone marrow transplantation, 48(9), 1243.

Figure 2 Kaplan–Meier OS curves of the two significant prognostic factors: response to Inolimomab (left, P<0.01) and age of patient (right, P<0.05).

Figure 2 Kaplan–Meier OS curves of the two significant prognostic factors: response to Inolimomab (left, P<0.01) and age of patient (right, P<0.05).

Girerd, S., Renaud, M., Guilhot, J., Giraud, C., Larchee, R., Jollet, I., & Guilhot, F. (2013). Long-term follow-up of corticosteroid refractory acute GVHD treated with an Inolimomab-based algorithm: a single center experience. Bone marrow transplantation, 48(9), 1243.


Specifications

  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • Inolimomab
  • Applications
  • ELISA, FuncS
  • Related Disease
  • Graft versus host disease

Applications

  • Application Notes
  • The antibody was validated for Function assay. For details, refer to Published Data.

Target

  • Alternative Names
  • IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Intrabody

CAT Product Name Application Type
IAB-B073(A) Recombinant Anti-human IL2RA Intrabody [(D-Arg)9] IF, ELISA, FuncS scFv-(D-Arg)9
IAB-B073(G) Recombinant Anti-human IL2RA Intrabody [+36 GFP] IF, FC, WB, FuncS scFv-(+36GFP)
IAB-B073(T) Recombinant Anti-human IL2RA Intrabody [Tat] WB, CO-IP, FuncS scFv-Tat

Humanized Antibody

CAT Product Name Application Type
TAB-023 Anti-Human CD25 Recombinant Antibody (Daclizumab) ELISA, Neut, IF, IP, FC, FuncS IgG1 - kappa
TAB-646LC-F(E) Anti-human IL2RA Fab Fragment (48M54S) ELISA, FC Humanized antibody
TAB-647LC-F(E) Anti-human IL2RA Fab Fragment (48M51L) ELISA, FC Humanized antibody
TAB-648LC-F(E) Anti-human IL2RA Fab Fragment (48V54S) ELISA, FC Humanized antibody
TAB-649LC-F(E) Anti-human IL2RA Fab Fragment (Dmab) FC Humanized antibody

Chimeric Antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L028E anti-IL2RA immunotoxin RFT5 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L028D anti-IL2RA immunotoxin RFT5 (IgG)-DT Cytotoxicity assay, Functional assay
AGTO-L078E IL2-PE immunotoxin Cytotoxicity assay, Functional assay
AGTO-L078D IL2-DT immunotoxin Cytotoxicity assay, Functional assay
AGTO-L078R IL2-RTA immunotoxin Cytotoxicity assay, Functional assay

Neutralizing Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1350CQ Mouse Anti-IL2RA Recombinant Antibody (clone 2R12) Block, FC, ICC, IF, IHC, IP, WB Mouse IgG1
NEUT-1356CQ Rat Anti-Il2ra Recombinant Antibody (VMC199) FC, IP, IHC, Block, Depletion Rat IgG1, λ
NEUT-1357CQ Rat Anti-Il2ra Recombinant Antibody (clone 3C7) FC, IP, Inhib Rat IgG2b, κ
NEUT-1358CQ Rat Anti-Il2ra Recombinant Antibody (clone mAb0817) Block, Depletion Rat IgG1
NEUT-1359CQ Rat Anti-Il2ra Recombinant Antibody (clone mAb0845) Block, FC, IHC-Fr, IP Rat IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1808 Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB) IHC, ICC, IP Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-004 Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Basiliximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-023 Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Daclizumab), ADCC Enhanced ELISA, Neut, IF, IP, FC, FuncS ADCC enhanced antibody
AFC-TAB-155 Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Inolimomab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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