Human Anti-IL17A Recombinant Antibody (VS-0624-FY63)
CAT#: VS-0624-FY63
HB0017 is a human recombinant antibody that has a specific binding affinity to human IL-17A. This antibody, HB0017, has exhibited robust recognition of human, monkey, and mouse IL-17A, which could potentially be attributed to the presence of highly conserved epitopes for HB0017 within the IL-17A protein families.
The clone 11.003 epitope on human IL-17A is primarily located within the first and second β-hairpin structures of a single IL-17A subunit. The IC₅₀ value is 33.9 ± 16.8 nM.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows distinct positivity in peripheral leukocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_6.jpg
Normal Tissue
Figure 7 Tonsil
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52258/119541_A_4_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (Karpas-707, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000112115-IL17A
❮
❯
| Sub Cat | Clone | Species Reactivity | Applications | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0624-FY16 | HB0017 | Human, Monkey, Mouse | ELISA, Neut, IHC | ||||||
| VS-0624-FY17 | 11.003 | Human | ELISA |
Specifications
- Immunogen
- Recombinant human IL-17A protein
- Host Species
- Human
- Type
- Human IgG
- Specificity
- IL17A protein of human, monkey and mouse origins.
- Related Disease
- Autoimmune disease
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Interleukin 17A
- Gene ID
- 3605
- UniProt ID
- Q16552
- Long Name
- Interleukin 17A
- Sequence Similarities
- Belongs to the IL-17 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- N-glycosylated. Found both in glycosylated and nonglycosylated forms.
- Protein Refseq
- NP_002181.1
- Function
- Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361).
Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:19825828, PubMed:21350122, PubMed:17911633, PubMed:18684971, PubMed:8676080, PubMed:24120361).
Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity).
In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity).
In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity).
Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (By similarity).
Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (By similarity).
Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection (PubMed:21350122).
Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity).
As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity).
In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity).
Involved in antiviral host defense through various mechanisms (By similarity).
Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity).
May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity).
Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity).
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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