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CD19 & FcαR
Engineered Antibody Products
Glyco-Engineering Antibody Products
Antibody Magnetic Beads
AbPlus
Recombinant Antibody Products
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Formats
Anti-CD19 & FcαR Recombinant Antibody Products
- Anti-CD19 (clone hBU12)-vcPAB-MMAE ADC (ADC-150CL)
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- Target: CD19
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD19 (clone BU12)-MC-MMAF ADC (ADC-189CL)
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- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD19 (hBU12)-mcMMAF ADC (ADC-017LCT)
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- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-CD19 (hBU12)-Mc-MMAE ADC (ADC-019LCT)
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- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD19 (huB4)-SPDB-DM4 ADC (ADC-020LCT)
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- Target: CD19
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Anti-CD19 (Denintuzumab)-Mc-MMAF ADC (ADC-175LCT)
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- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Host Species: Mouse
- Specificity: Human
- Type: Mouse antibody
- Glycosylation site: Fc region
- Glycoform (ratio): G2-NANA
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- Host Species: Human
- Specificity: Human
- Type: Humanized antibody
- Glycosylation site: Asn297 in Fc region
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- Host Species: Human
- Specificity: Human
- Type: Humanized antibody
- Glycosylation site: Asn297 in Fc region
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- Anti-CD19 (clone B496)-mc-MMAF ADC (ADC-184LZY)
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- Target: CD19
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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- Anti-CD19 (hBU12)-Mc-MMAF ADC (SGN-19A) (ADC-L034)
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- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Target: CD19
- Linker: mc-vc (maleimidocaproyl-valine-alanine)
- Drug: pyrrolobenzodiazepine (PBD) dimers SGD-1882
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- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Glycosylation site: Asn297 in Fc region
- Glycoform (ratio): GN-GN-M-(M-GN)2
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- Host Species: Human
- Specificity: Human
- Type: Chimeric antibody (mouse/human)
- Glycosylation site: Asn297 in Fc region
- Glycoform (ratio): GN-GN-M-(M-GN)2
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- Anti-CD19 (clone huB4)-mc-MMAF ADC (ADC-045LZY)
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- Target: CD19
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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- Anti-CD19 (clone huB4)-SMCC-DM1 ADC (ADC-157LZY)
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- Target: CD19
- Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-CD19 (clone MDX1435)-vc-duocarmycin ADC (ADC-163LZY)
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- Target: CD19
- Linker: VC (valine-citrulline)
- Drug: duocarmycin
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- Anti-CD19 (clone B496)-SPP-DM1 ADC (ADC-181LZY)
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- Target: CD19
- Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-CD19 (clone B496)-MCC-DM1 ADC (ADC-182LZY)
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- Target: CD19
- Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-CD19 (clone B496)-mc-vc-PABC-MMAE ADC (ADC-183LZY)
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- Target: CD19
- Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
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For Research Use Only. Not For Clinical Use.
CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor.
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Related Diseases
Primary Immunodeficiency