HER2 & CD3
Anti-HER2 & CD3 Recombinant Antibody Products
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- Application: FC, IB, ELISA
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- Type: Humanized Antibody
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus Monkey
- Type: Humanized Fab
- Application: ELISA, SPR
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, ELISA
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus Monkey
- Type: Humanized Fab
- Application: ELISA, SPR
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- Type: Human antibody
- Application: FC, Cyt
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- Type: Human antibody
- Application: FC, Cyt
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- Type: Human antibody
- Application: FC, Cyt
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Fab fragment
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus Monkey
- Type: Humanized scFv
- Application: ELISA, SPR
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus Monkey
- Type: Humanized IgG
- Application: ELISA, SPR
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus Monkey
- Type: Humanized scFv
- Application: ELISA, SPR
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, ELISA
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus Monkey
- Type: Humanized IgG
- Application: ELISA, SPR
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human IgG1, κ
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC, FuncS
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: FC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: FC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: FC, WB
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- Species Reactivity: Cynomolgus, Human
- Type: Mouse IgG
- Application: ELISA, SPR
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Species Reactivity: Cynomolgus, Human
- Type: Mouse IgG
- Application: ELISA, SPR
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Cynomolgus, Human
- Type: Mouse scFv
- Application: ELISA, SPR
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- Species Reactivity: Cynomolgus, Human
- Type: Mouse scFv
- Application: ELISA, SPR
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Llama VHH
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Llama VHH
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA
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- Species Reactivity: Human, Non-human primate
- Type: Mouse IgG1, kappa
- Application: IHC, FC
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- Species Reactivity: Cynomolgus, Human
- Type: Mouse Fab
- Application: ELISA, SPR
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- Species Reactivity: Cynomolgus, Human
- Type: Mouse Fab
- Application: ELISA, SPR
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.